Psychosocial and cognitive approaches don't require that you become a clinical psychologist but that you have a broad concept of the influence of those factors and that you account for them in your encounters with your patients. Know the literature and be able to give management advice based on evidence. When people come to see you they want a plan. Have a plan that is defensible and that works toward their goals. Address concerns, fear avoidance, other stress, and unhelpful beliefs with compassion, understanding, empathy, and informed knowledge.
Understanding why people hurt is part of our professional responsibility and should change most everything we do on a daily basis away from traditional methods and towards methods defensible with modern science.--Jason Silvernail accessed 5 August 2011
Since I'm advocating massage in a biopsychosocial model, it's my job to connect the dots and explain what I mean by that.
A biopsychosocial model of health and illness is one that takes into account the role of biology (and other sciences), psychological factors, and sociocultural factors, as well as the interactions among those different factors, in seeking to understand what health and illness really are.
An example of a biological factor in health could be increased cortisol in the bloodstream in response to chronic stress. The interaction of that biological factor with the increased daily stress in modern society would be an example of interactions among biological factors and sociocultural factors.
An example of a psychological factor in health could be a man who is less likely to seek professional treatment for pain than a woman is, because of his perception that stoically enduring pain is what men do in the society he grew up and lives in. The increased structural damage that can occur as a result of ignoring symptoms and delaying treatment is an example of the interactions among psychological factors and biological factors.
An example of a social factor in health could be the relative stigmatization of mental or behavioral illness, as compared to how more clearly structural conditions are regarded. This stigmatization can drive psychological conditions underground--say, for example, if someone did not get needed psychological treatment because they didn't want it to show up in their medical record. That would be an example of interactions among sociocultural factors and psychological factors.
Biopsychosocial massage is client-centered. That means that the psychological and social factors in the client's unique experience, as well as the universal biological factors we are all subject to, is the center of where we focus our attention and caring. It doesn't mean that we accept everything in someone else's experience is literally true. It does mean that we recognize that, for them it feels true, and for that reason alone, it is important in where we meet the client in the therapeutic encounter.
Biopsychosocial massage welcomes self-expression and the art of massage. It is clear, however, that sometimes our need for self-expression can come into conflict with clients' immediate healthcare needs, and--when that happens--we recognize that, in order to act as healthcare professionals, our ethical fiduciary duty is to put the clients' needs first, ahead of ours if necessary.
Biopsychosocial massage is wholistic, integrative, and evidence-based. That means that it does not draw upon supernatural explanations of mechanisms, and it builds upon foundational knowledge in the sciences to evaluate and validate the evidence for or against particular claims of effectiveness or mechanisms.
Since our encounters with clients will always run ahead of the available high-quality evidence, we don't limit ourselves only to what has been rigorously validated by studies and nothing else. We take our professional experience into account, and we actively seek to understand and incorporate the clients' preferences, whenever possible, in treatment. But in all these cases, in developing our approach to caring for the client, we remain clear on what is evidence, what is speculation, what is science, what is art, what is literal, and what is metaphor.
Understanding the material physical universe around us, and the centuries of cumulative human knowledge about that universe, give us powerful tools to draw upon. That understanding, combined with the caring that characterizes so many people who choose to go into massage as a career, is the heart of biopsychosocial massage.
Neil deGrasse Tyson sums it up almost perfectly:
I am driven by two main philosophies, know more today about the world than I knew yesterday. And lessen the suffering of others. You'd be surprised how far that gets you.
--Neil deGrasse Tyson
That quotation demonstrates the core of massage in a biopsychosocial model.
In accordance with the fair use exception to copyright for teaching purposes, I am engaging with it here to bring out points that are directly relevant educationally to stakeholders in the massage community, and to provide links to clarify specialized knowledge as needed.
Where did the idea that massage promotes metastasis, and therefore, we shouldn't offer massage to patients living with cancer, come from?
What is the current best practices recommendation for massaging someone with a history of cancer, and on what basis is that best practices recommendation formed?
Why is the idea that we shouldn't massage someone with a history of cancer, because it might promote metastasis, so persistent in the face of what we actually know?
We're going to discuss meaning a great deal in this post, so it's useful for understanding if we're all on the same page about that.
That way, when we're trying to navigate among terms, concepts, and referents in discussing this article to get at what it all means, we have the advantage of a shared vocabulary and approach to help us work together with each other.
ANNALS of SURGERY VOL. LXXV FEBRUARY, 1922 No. 2
THE RELATIONSHIP OF MASSAGE TO METASTASIS IN MALIGNANT TUMORS*
* From Columbia University, Institute of Cancer Research, F. C. Wood, M.D., Director, New York.
BY LEILA CHARLTON KNOX, M.D. OF NEW YORK, N. Y.
CLINICAL
One of the most important aspects of the practical study of tumors is the determination of the anatomical and biological conditions which facilitate or prevent metastases. These phenomena have long been studied in man without much definite information having been collected. About all we know is that, in general, carcinomata are prone to metastasize through the lymph-channels and sarcomata through the blood-vessels, and that metastases do not always follow in the direction of flow of the current, but in a certain proportion of instances the emboli travel by a retrograde course or the tumors progress by direct extension, the so-called permeation of the lymphatics.
What are the important points that Knox is making here?
Structually, what part of the research article that you would expect to see here is missing? What might be a reason that this research review article does not have the structure that you would normally expect?
It has been generally assumed, without direct experimental proof, that a number of the factors favoring the production of metastasis are purely physical, for instance, the size and connective-tissue relations of the tumor cells, the pulsating or contractile movements of the organs in which they are implanted, the number of the blood-vessels and the thickness of their walls, with consequent susceptibility to trauma by pressure or massage. On the other hand, accurate clinical study and experimental work as well have caused the occult and convenient theories of tissue predispositions and specific "immunity" of organs to assume a less creditable position than they formerly held, and quite properly, for until it is shown that simple mechanical and biological facts do not account for the peculiarities in the occurrence and distribution of metastases vague theories should not be substituted.
What exactly is she saying here about material mechanical and biological facts?
Is she arguing from a realist position or not? How do you know?
At this point, unless we have some specific knowledge of particular claims about metastasis made at this time in history, it's unclear exactly what she means by "occult and convenient theories of tissue predispositions and specific "immunity" of organs". At a very general level, however, what does she appear to be talking about? Remember this point--she'll clarify it later in her discussion.
Where does she use Occam's Razor in her argument here, and why?
The importance of vascular embolism in the spread of tumors has long held an unchallenged position in instances in which the pulmonary veins were known to be grossly involved and the arterial circulation in that way obviously open to a supply of tumor cells. A valuable contribution on this phase of the subject was made when M. B. Schmidt showed that not infrequently the tumor cells readily pass the pulmonary capillaries and are deposited elsewhere before macroscopic growth appears in the lung. In a study of forty-one cases of primary abdominal carcinomata without extensive gross metastases, the lungs of fifteen were found to contain microscopic arterial emboli of tumor cells, showing that once the cells gain entrance to the blood stream they may reach any portion of the body and are not necessarily always retained or destroyed within the lungs. This may, however, be their fate, for Schmidt found many small thrombosed vessels with degenerating tumor cells entangled in the clot. These phenomena have been duplicated experimentally by Takahashi and by Iwasaki, both of whom injected tumor cells into the blood stream of animals. Both these authors have well shown that although embolic cells are frequently treated as foreign bodies and phagocyted, many, on the contrary, survive the adverse conditions, and invade and replace the vascular endothelium or undergo mitosis even before they become implanted on the vessel wall.
What does she mean by "the pulmonary veins were known to be grossly involved and the arterial circulation in that way obviously open to a supply of tumor cells"? Describe the relationship between pulmonary veins and arterial circulation that she is referring to.
What is M.B. Schmidt's valuable contribution on the subject, and why is it so valuable?
What did Takahashi and Iwasaki show, and what does it mean?
Notice the unusual term "phagocyted"; it means the same thing as "phagocytosed", which is the term you see more often nowadays, as in this example from Wikipedia:
Phagocytosis (from Ancient Greek φαγεῖν (phagein) , meaning "to devour", κύτος, (kytos) , meaning "cell", and -osis, meaning "process") is the cellular process of engulfing solid particles by the cell membrane to form an internal phagosome by phagocytes and protists...Bacteria, dead tissue cells, and small mineral particles are all examples of objects that may be phagocytosed.
For purely physical reasons, however, we must suppose that cells of small size accomplish this more readily than do larger ones, and experience shows that the large spindle and giant cells, or those distended with mucus as many from the gastro-intestinal tumors are, do not find their way through the pulmonary capillaries except in small numbers. Whether or not the ameboid motion of the cells is a factor in facilitating this is not known. That such motion exists was shown by Carmalt in 1872 and later by Lambert and Haynes.
What are two possible physical explanations that could account for smaller cells establishing metastases beyond the lungs more successfully than larger cells do?
The localization and growth of embolic tumor cells within the dilated capillaries of the bone-marrow have been explained as due to the physiological hyperaemia which is practically constant in that situation. Slowing of the blood current and adhesion of the tumor cells to the endothelium seems to produce circumstances favorable to the growth of such emboli.
Is she saying that bone marrow is particularly susceptible to metastasis from tumors that originated elsewhere in the body? Why or why not?
Lymphatic embolism, either direct or retrograde, has also been unquestionably a frequent and important means of tumor dissemination; but the status of lymphatic permeation, although very convincingly demonstrated by Handley in certain cases, is perhaps a less constant phenomenon than he at first believed.
Notice the British spelling of "tumour", and beware the typo in "pulmonary"--this image was probably created by a non-native English speaker, but is factually correct with regard to the referent, although they misspelled the term.
Tell me what we're looking at here--what structures and processes do you see?
The process, as Handley described it, consists in the proliferation of tumor cells which, having gained access to the superficial lymphatics in the proximity of the tumor, continue to grow within them and to extend through their branches, often appearing in the skin, where they form cutaneous nodules. Secondarily, there often occurs an inflammatory fibrosis and obliteration of portions of the lymph-channel, a process analogous to the thrombosis which is common in invaded vascular channels. Handley studied especially breast carcinomata and melanomata--two of the tumors which most frequently exhibit regional cutaneous recurrences and extensions; and it is on the basis of his evidence that one may perhaps regard some of the recurrences in surgical scars as accidental occurrences due to the proliferation of tumor cells present in the lymphatics prior to the incision, though possibly accelerated in growth by the increased vascularity of the wound area. Probably, however, a majority of the local recurrences are due to a mechanical transplantation from an infected to a non-infected field.
What metastases do breast cancer and melanoma frequently exhibit?
What is the connection between metastasis and surgical scars?
What are 2 possible mechanisms for their occurrence?
Notice the use of "infected" to refer to cancer cells here.
FIG. 1.-Metastasis of breast carcinoma in pectoralis muscle following massage in man.
What different kinds of cells and other material physical things do you see there?
What indicates that you are looking at muscle cells?
What, particularly, indicates the pectoralis muscle?
In the case of the melanomata this mechanical transfer by operation is not a completely adequate explanation, for the nodules are often found far from the region of the incision, and, indeed, are frequently seen in unoperated cases, giving a striking illustration of the fact that tumor cells, especially those of moderate size, have the capacity to invade the cutaneous lymphatics for long distances and to spread against the direction of flow of the lymph. When the vessel is large, as in the abdominal trunks, permeation would not be expected to occur, and it is probable that extensive backward spread of tumor cells is due to a combination of several processes. Vogel has described two such cases, one a carcinoma of the gall-bladder, which extended into the left kidney hilus [RST: This is an old name; it means the same thing as "hilum"] and there perfectly outlined the perivascular lymphatics of that region; the other a pancreatic carcinoma which extended directly along the mesenteric and aortic trunks into these nodes.
What are two explanations that Knox provides for why surgery is not the only thing that accounts for metastasis?
Vogel described two cases where the spread was far away, and it travelled retrograde to the direction of lymphatic flow.
In what direction did the gall bladder tumor have to travel to reach the hilum of the kidney?
How far did it have to travel?
What did it have to pass through to get there?
Where have we seen a hilum of an organ before in this discussion? What do they have in common with each other?
It is well known also that oesophageal carcinomata are prone to spread longitudinally along the lymphatics of the submucosa and that small secondary nodules often appear considerably below and separated from the oldest portion of the tumor by uninvolved mucosa. It used to be the fashion to describe these as implantation growths, but this view is now generally abandoned. Zahn has even described one situated as high as the tracheal bifurcation, but associated with three small carcinomatous nodules beneath the mucosa on the gastric side of the cardia. This occurred also in an oesophageal carcinoma with tracheal fistula (St. Luke's Hospital, No. 1309), the secondary nodule being 4 cm. from the main mass of the neoplasm. The mechanism of the formation of these multiple nodules, as well as of multiple papillary gastric carcinomata, has not been shown to be necessarily a process of permeation, although theoretically this would readily explain their occurrence.
"Oesophageal" is an older, Latin/Greek-based, spelling for "esophageal".
Why does the esophagus have carcinomata?
If you're a tumor cell, how far away is 4 cm in proportion to your size?
At the time Knox wrote this, did they know the mechanism by which these secondary metatastic tumors got away from the primary tumors?
On the other hand, emboli are, no doubt, prevented from growing by the mechanical activity of muscles and muscular organs. Metastases are singularly rare in the cardiac muscle, being practically never seen except in the case of extremely vascular tumors with scanty stroma from which the loosened cells spread and overwhelm the whole arterial circulation with countless emboli. The aortic valves must also act to deflect emboli from the mouths of the coronary arteries. Benecke, studying the invasion of the walls of vessels from carcinomatous thrombi, believed that the infrequency of metastasis in the muscular coat was due to the physiological tonus of the muscle. This is a reasonable conclusion, and the principle holds good for striated muscle as well. Metastases into the latter are extremely rare, due in part to the contractility of the fibres, a condition which offers considerable resistance. The fact that lymphatics are lacking within striated muscle bundles is certainly not the reason for the rarity of metastases, for if the emboli were lymphatic, not vascular, and if the motion did not play so large a part in preventing their growth, they should be present in tendons where lymphatics are very numerous. Direct permeation of both striated and unstriated muscle is, however, frequently seen, showing that the soil is not unsuitable provided the cells once gain access to the tissue.
What protects muscles, and muscular organs like the heart, against metastasis?
Does this protection always work perfectly?
How do we know that it's not just the lack of lymphatic vessels in skeletal muscle that protects them?
Normal peritoneum has been shown by Jones and Rous to possess a high resistance to the implantation of tumor cells, but when it was injured by a mechanical irritant, tumor growth was at once made possible. This offers an explanation for the frequently observed fact that carcinoma of the stomach often metastasizes into the ovary, producing the so-called Krukenberg tumor of the latter organ, without any intermediary deposits on the peritoneal surface. That such deposits will eventually occur in late stages of carcinomatosis is, of course, well known, but it is probable that the constant motion of the opposed serous surfaces is an important factor in destroying whatever cells may find their way to it. It has long been recognized that it is the gelatinous carcinomata of the ovary, stomach, and intestine that are most widely distributed in the abdominal cavity. This is, of course, as would be expected, for the bulk and consistency of the mucus make it in a sense a foreign body and must keep the cells in contact with the peritoneum and also irritate it, and so indirectly facilitate adhesion and ultimate vascularization, whereas a few free cells would be more likely to be destroyed.
Is peritoneal tissue normally relatively vulnerable or relatively resistant to metastasis?
What is a proposed mechanism that could account for that tendency?
What can change that tendency?
Post-operative human results have occasionally shown the remarkable persistence which cells from malignant tumors may exhibit. During the quiescent period the cells are probably most frequently inactive in the lymph-nodes, occasionally for as long as ten to twenty years. Late recurrences usually appear first in the nodes to which drainage was directed, and if the morphology of the tumor is that of the primary growth there can be no question that these are really late recurrences from previous metastatically deposited cells. For example, small groups of living cells from a gastric carcinoma have been observed by Rohdenburg in the liver and omentum ten years after the operation on the primary tumor, with a clinical cure. Such a case may be the result, like many of the very late cutaneous recurrences from breast tumors, of slow permeation along the efferents of a node or even from a small group of cells for years quiescent in the tissue spaces.
How long after a tumor is removed can a recurrence or metastasis happen?
How can it do that, since the tumor was removed?
How can they tell it was a recurrence of the old cancer, rather than the development of a brand-new different cancer?
A spindle-cell sarcoma has occasionally recurred after a very long period. A tumor of this type, originating in the cervical fascia, has been seen by the writer recurring as a mass the size of a walnut twelve years after the first operation, the patient being free from symptoms during the greater part of the period. Such a phenomenon is difficult to explain, since only rarely does this type of sarcoma metastasize into the lymphnodes, and there form a focus for new growth. As this recurrence was in the centre of a large skin graft made at the first operation, it seems more probable that it was a recurrence in situ of very slowly growing cells situated in the deep fascia below the graft.
What happened in this case?
Was it what you would usually expect?
How does Knox explain it?
Other rare and late metastases which give no hint as to the mechanism of their localization and long course are cited by Schmidt and Goldmann, who observed a cerebral metastasis four years after a rectal carcinoma with no local or lymphatic return. Schmidt believes that such tumors are derived from latent intravascular cell groups in the pulmonary vessels. Another still more remarkable observation is that of Crouzon, who described a cerebral metastasis eighteen to twenty years after operation on a bilateral breast carcinoma. Gathmann and Schmidt have each observed cases in which four years after operation on similar tumors, with apparent cure, widespread skeletal metastases appeared. In such a case a general emboli distribution of cells by the blood into the capillaries of the myeloid canals must have occurred fairly early, and the growth processes have been very slow.
What happened in these cases?
Why are they so surprising?
How does Knox explain these events?
The frequency of skeletal metastases is so much greater than can possibly be demonstrated by clinical or röntgenological means until a very advanced stage that the high percentage of such growths is not often appreciated. Although the vascularity of the marrow is great, the stroma reaction may be here as marked as elsewhere and the metastasis of a scirrhous breast carcinoma be only a sclerotic nodule of the same appearance as the primary growth. When the bones are noticeably eroded or spontaneous fractures occur the process is far advanced and statistics drawn from such cases only give misleading data as to the frequency of the process.
"Röntgenological" is an old-fashioned word for "x-ray", because in 1895 the German physicist Wilhem Röntgen was the first person to discover x-rays in nature.
Is the skeleton particularly resistant to metastasis?
What does that translate to in clinical observations?
This view of the localization of metastases has not, however, been universally accepted, and many convenient hypotheses have had to give way to the increasing weight of pathological and experimental evidence. The theory of the specific adaptation of some tissues, as the liver, for neoplastic cells, and the relative immunity of others, as the brain, has been prevalent in the literature for many years. Virchow stated that organs in which carcinoma is never primary do not serve as a site for metastases. Recent observation has shown these conclusions to be wholly incorrect, as the brain is the site of secondary metastatic carcinomatous deposits in at least 0.3 per cent. of all autopsies (Krasting). Adherents to this theory point out, however, that some types of tumors have distinctly greater capacity to metastasize into certain organs than others, since not all tumor cells readily grow within the bones, but others very commonly do so, as those of the breast, thyroid, adrenal and ovary. Von Recklinghausen even advanced the idea that breast and prostatic carcinomata were apt to form metastases in similar regions because they were in a sense analogous organs, each being a part of the genital system. Bamberger and Paltauf believed that there was some specific organ susceptibility, and offer as evidence the fact that not only the small-cell carcinomata of the prostate metastasized to the bones, but the large-cell medullary carcinomata of the gland behaved in the same way.
Remember earlier, when she mentioned "occult and convenient theories of tissue predispositions and specific "immunity" of organs"?
What are some of those theories?
Rudolph Carl Virchow is called the "father of modern pathology", because of all the discoveries and knowledge contributions he made. Was he correct about metastasis sites? Why or why not?
When it comes to the concepts and terms of a big name, versus material physical referents, which do we believe, and why?
What is the other choice of belief called? Is it a logical fallacy?
The spleen also has been called "immune" to metastases by various writers because gross tumors in it are not especially frequent and microscopic ones often escape detection; but late stages of breast carcinoma are not infrequently accompanied by palpable enlargement of that organ due to a diffuse carcinomatosis, while E. E. Goldmann demonstrated that animal tumors inoculated into the spleen grow as readily there as elsewhere. While the vascularity of the organ exposes it to numerous emboli, yet as it possesses no efferent lymphatics and is in practically constant motion, embolic cells can not proliferate within it with as much facility as in some other organs. The great vascularity of the adrenals, as well as their protected position and absence of intrinsic motion, provides a suitable location for the secondary growths so often found in them. It is possible that the wide vascular sinuses of the pituitary, which resemble those in the adrenal, facilitate the location of metastatic tumors in this organ as well.
Again, this is an example of the "occult and convenient theories of tissue predispositions and specific "immunity" of organs" she referred to earlier.
Is the spleen immune to metastases? What does the evidence say?
How about the immunity or vulnerability of the adrenal glands and the pituitary? What might explain their situations?
External mechanical influences have for some years been recognized as an important factor in dealing with any malignant tumor. Gerster, in 1885, discussed the apparent breakdown of the forces which keep a malignant tumor for a time localized, and believed them to be largely mechanical. He pointed out the need, for example, of high amputation, not alone for the purpose of obtaining an uninfected field, but in order that the neoplasm itself should be free from manipulations, and so facilitate cellular dissemination. This writer further compared the results of malignant tumor massage to that which is sometimes effected by massaging a sprained joint--a process which certainly disseminates inflammatory exudate rapidly and widely. The effect of pressure, rubbing, or active massage on the tumor has been frequently observed in human beings as the result of osteopathic or massage treatment of malignant tumors, and many examples have been seen in recent years of wide dissemination of a primary growth very effectively accomplished by this procedure.
What were the two reasons Gerster advocated amputation in the case of cancer?
What is the analogy he drew with massage?
Does the evidence back up that analogy?
Such an instance has recently occurred at St. Luke's Hospital, and furnishes one of the rare instances in which extensive gross metastatic invasion of muscle could be observed. The patient stated that massage treatment had been regularly employed for some time previous to admission. When the breast tumor was examined there was found a fairly extensive area of eczema overlying a large very hard tumor which was fixed to the pectoralis fascia. Small white tumor nodules were scattered widely throughout the muscles, even invading the individual fibres. (See Fig. 1.)
What was unusual about this patient's case?
Does the evidence back up Knox's claim that massage accomplished this metastasis?
EXPERIMENTAL
While, therefore, much interesting and important information has thus been obtained by clinical, operative, and post-mortem studies, the number of cases is too small to enable final conclusions to be drawn.
Is this consistent with everything that Knox said earlier?
The determination of the weight of a factor in producing metastases can not be judged from single experiences on man, as it is impossible to eliminate conflicting conditions. Only by the use of a homogeneous material in which the size of the cells, their histological and biological qualities, and the vascularity of the surrounding tissue, etc., are practically constant can valid conclusions be drawn, and this elimination of variables is possible to obtain only by the use of animal tumors of a long transplanted strain, so that the morphological and biological characters are well known. The possibility of obtaining by inoculation in a single day more tumors than any one surgeon observes in a lifetime of active practice also eliminates the occurrence of errors due to random sampling affecting the result--a condition never possible in human material. For example, following the discussion produced by the publication from the Crocker Fund of a paper on the results of the incision of tumors, many surgeons brought forward individual instances which they thought were of value in proving the danger of diagnostic incision, not realizing that from a statistical aspect a single instance is of no value. Even from a basis of reasoning, so remote from the complexities of mathematics as what is ordinarily termed common sense, many of those who cited these single instances were unable to deny on cross examination that pre-operative manipulation by the patient, or that dragging or pressure on the tumor during the operation might have equally well caused the evident dispersal of tumor particles, as evinced by the subsequent course of events.
What is she saying here about individual observations? About confounds?
It was not until Tyzzer, in 1913, demonstrated that gentle massage of a transplanted carcinoma in a mouse greatly increased the number of metastases observed in the lung that definite evidence was brought forward to substantiate these occasional clinical observations. The number of Tyzzer's experiments was small, and he obtained results with only one tumor, a highly malignant neoplasm of the Japanese waltzing mouse. With the Ehrlich mouse tumor No. 11 and the Jensen rat sarcoma he was unable to obtain metastases artificially by massage of the implanted tumors. Rous states that his experiments in massaging rats with adenocarcinoma resulted in the death of all the animals, but did not cause more than the ordinary number of metastases.
What did Tyzzer's and Rous' studies demonstrate? Were they definitive?
Several recent clinical experiences of the writer in which after the removal of a very small primary tumor of the breast by perfect surgical technic (no involvement of the axillary nodes being present), the patient died of generalized carcinoma in a short period thereafter, pointed to the desirability of further extension of Tyzzer's experimental results. We will say, in passing, that in one of these human tumors which had been somewhat vigorously palpated by a number of physicians, a small hemorrhagic area was found in the middle of the growth, and in the vessels surrounding the tumor numerous emboli of cancer cells were present.
What is the clinical relevance of Tyzzer's and Rous' studies?
What did the physical evidence show in one case?
What does this table tell us?
A considerable variety of transplantable carcinomata or sarcomata of the mouse and rat were used for the experiment. Some of these tumors under normal conditions, especially the spindle-cell sarcomata, do not produce spontaneous metastases in the animals in any number. Others, especially the carcinomata, are apt to metastasize early.
What were they comparing in this experiment? What is the internal validity likely to be?
The following tumor strains were employed: Crocker Fund mouse carcinomata, Nos. 5, 11, and 48, the Borrel mouse carcinoma, the Ehrlich mouse carcinoma and the Flexner rat carcinoma; Crocker Fund mouse sarcomata Nos. 7 and 180, and the Ehrlich mouse sarcoma.
The method employed was as follows, with the exception of the two series described separately below: The animals were inoculated subcutaneously in the inguinal or axillary region with a tumor particle weighing about 0.003 gm. When the tumor reached a diameter of approximately 5 mm. it was gently massaged for half a minute every other day for about two weeks. The tumor was then removed by operation to prevent further metastasis, in order to obviate the difficulty of having to decide whether embolic masses in the vessels of the lung were really growing tumor particles, or only recently deposited emboli which might ultimately die without giving rise to a tumor nodule. In the final results only those masses are considered as true metastases in which the vessel wall was invaded, a separate column giving the number of instances in which emboli were found in the lumen of the pulmonary vessels.
What were they studying in this experiment? What did the method provide?
In one series, mouse carcinoma No. 11, the experiment was repeated, and the technic was varied as follows: The tumor was massaged vigorously for one minute on each of two consecutive days. After the second massage treatment all tumors, both controls and those which had been manipulated, were excised and the animals all killed twenty-seven days later. (No. 11, Series II.)
In order to check the results a third series of mice were inoculated two years after the first lot with the Crocker Fund mouse sarcoma No. 180. The mice were all of the same breed, and the conditions were kept as nearly as possible the same as in the preceding experiments. This time the mice were inoculated in the right axillary region, and as soon as the tumors were easily palpable the massage was begun on one-half of the mice, the others being reserved for controls. As before, the massage was carried out for thirty seconds on alternate days for about two weeks. The tumors were then very large, and many of the mice died at this time. In those surviving the tumors involved the thoracic wall too extensively to make removal feasible, so the aninmals were, therefore, allowed to die and then were autopsied. The results of this experiment are recorded as No. 180, Series II.
What does the variation in the method mean for the validity of the study?
In all the series the lungs were carefully removed, distended through the trachea with 4 per cent. formaldehyde, and hardened, and six sections from each animal were examined. Much difficulty was experienced in determining microscopically whether a mass of cells in a vessel should be considered as a true metastasis or merely an embolus. When emboli cease to be capable of forming a tumor we do not know. Careful morphological studies have been made by Takihashi and others to determine the early degenerative and proliferative changes which occur in emboli of tumor cells, but the two processes are frequently coincident, and, as many groups showed no evidence of either process even after being in the vessels many days, we cannot be too cautious in deciding whether a death point has been reached. Such emboli were found, for example, in specimens 9515, 6363, 6359, thirty-two, twenty-seven, and twenty-six days after removal of the primary tumor and no local recurrence at the site of inoculation had taken place from which such emboli could have been derived. Presumably such cells are dead; hence these groups have been called emboli, not metastases. In one sense, however, they are just as important as a growing lung tumor in showing that emboli of cancer cells can be set free in the blood stream by massaging a tumor, and any embolus in its early stage carries the potentiality of metastasis formation.
What is the meaning of the different kinds of things they found in the animal's lungs?
What do they tell us about massaging a tumor?
How meaningful is that for the kind of massage that we would do for someone living with cancer?
Only six sections of the lungs were studied, for it was found after a few complete sets of serial sections had been examined that the gain in number of emboli or small tumors discovered was unimportant.
This means that the distribution of emboli and small tumors was relatively uniform throughout the lungs they studied, and they were able to work with a smaller data set than they had originally thought they would need.
The tabulated records of the experiments are self-explanatory and need no further elucidation.
No, I disagree. Remember, a lot of the statistical tests that we presently use to interpret studies were being developed at about the same time as Knox wrote this article.
While I don't fault her for not using something that she didn't have access to in her time, it remains true that without those tools to interpret her results with, we necessarily have to consider them weaker than we would similar results that had stood up to robust statistical testing.
The point of these tests is to make sure that we are, in reality, seeing what we think we see. Without the assurance provided by those tests, such as tests of statistical significance, confidence level, and the like, we just cannot consider these results as explanatory and self-evident as she considers them.
DISCUSSION
Examination of the chart (Fig. 2) shows that, in general, with nine tumor strains, there was a more or less distinct increase after massage in the number of embolic particles in the lungs, the increase varying from 1 to 37 per cent.
FIG. 2.-Chart showing percentage of emboli (hatched areas) and of metastases (solid areas), and their relative numbers in controls and massaged animals. In each case the column at the right represents the massaged animals, that at the left, the controls.
Tell me, what does this bar mean?
What does this one mean?
What does this one mean?
What does this one mean?
What does this one mean?
Can you find any cases where the control animals had more emboli or metastases than the study animals did? How does Knox explain these unexpected results?
The actual percentages can be considered of little importance, and it is even surprising to find that the tendency is so general. With the carcinomata the results are in many cases unequivocal; for example, the Ehrlich carcinoma, at the time showing no regression and 75 per cent. of takes, in other words, in its positive phase, formed more than twice as many metastases after massage as without it. A similar condition obtained with the Borrel carcinoma, at that time spontaneously regressing in 50 per cent. of inoculations, but still showing numerous metastases after massage. The ratio is probably artificially high as the number of control animals which survived was very small.
"The actual percentages can be considered of little importance"? Well, no; they are vitally important to the question we are trying to answer.
You can see here a cultural shift in how science used to be interpreted from how it now is.
The emboli are found in both lymph-and blood-vessels, frequently in both locations in the same lung. The perivascular space can frequently be seen filled with cells from which the parenchyma is invaded, but the primary process is evidently in the vessels, as it is seen in all stages within them. The lymphatic system of the mouse being developed to a much less extent than in man, it may also be expected to show relatively less tumor involvement. One reason for this may very probably be, as is pointed out by Murray, that the lymphatics are so delicate and quickly obscured by an inflammatory reaction that metastatic particles apparently freely growing in the tissues may have originated from an embolus either in a lymph-vessel or the nodal capsule. In these studies, however, there is seldom room for doubt that the emboli are vascular in the great majority of cases. Multiple emboli nearly filling both large and small vessels of a lobe are occasionally found, in the controls as well as in the massaged animals, but cell groups are much more frequent in the treated ones.
The illustration (Fig. 3) is from a massaged animal which died twenty-four days after inoculation. Both proliferation and degeneration are seen, and most of the stages described by Takahashi may be found in some area.
FIG. 3.-Multiple emboli of tumor cells in pulmonary vessels of a massaged mouse tumor.
Which things in this slide are the vessels? Which are the emboli?
How can you tell the difference?
Fig. 4 (No. 18363) and Fig. 5. (No. 18319) each show a small embolus which is certainly undergoing dissolution, as the surrounding lung is well preserved, but the tumor cells stain poorly. The outlines of cell walls and the nuclear membrane are indistinct, and the cytoplasm granular.
FIG. 4.-Degenerative changes in cells of a tumor embolus in pulmonary vessels.
Can you see the embolus clearly?
What is different about the pulmonary vessel the tumor embolus is in, compared to the other blood vessels in this slide?
FIG. 5.-Embolus of tumor cells in pulmonary vessel. Embolic cells are undergoing early degenerative changes. The lung tissue is well preserved.
What is the meaning of her explanation here?
On the other hand, occasionally even small emboli may be seen in which the actively invasive tendency of the tumor cells is plainly demonstrated.
Fig. 6 (No. 18322) shows a small embolus which has apparently lifted up the endothelium from the vessel wall and so given itself a fibrous surface upon which to obtain a footing.
FIG. 6.--Endothelium of vessel containing embolic tumor cells stripped from wall. Early stage of attempt to localize.
Tell me, what do you see here?
What do you see here?
What looks to you like an "attempt to localize"?
Another phase of apparently successful implantation is shown in Fig. 7 (No. 18343), where a number of well preserved tumor cells are growing in direct continuity with the endothelium.
FIG. 7.--Later stage in implantation of embolic tumor cells. A few have replaced the endothelium.
What do you see here? Where do you think the emboli have replaced the endothelium?
Figs. 8 and 9 show two small pulmonary emboli from a case of carcinoma of the stomach in a human being. In Fig. 8 there is no adhesion of the embolus to the endothelium, although nearly a third of the mass is made up of mucus produced by the epithelial cells;
FIG. 8.--Small embolus from case of carcinoma of stomach in man, showing invasion of pulmonary vessels. Nuclei surround a central mass of mucus.
Where do you see the vessel here? The nuclei? The mucus?
in Fig. 9 one cell only appears to have invaded the endothelium.
FIG. 9.--Beginning adhesion of tumor cells to endothelium in pulmonary capillary from case of carcinoma of stomach in man.
What structures and processes do you see here?
Another lung furnishes a picture of a more advanced stage of invasion, Fig. 10 (No. 18384). The endothelium can no longer be distinguished, as practically the whole circumference of the muscularis is lined with the tumor cells, and the lumen is almost filled with a carcinomatous embolus in which early degenerative or thrombotic changes have occurred [sic]. Similiar parietal thrombi were examined by Schiedat throughout their length and were found to extend for some distance along the surface of the wall and eventually to break through it.
FIG. 10.-Embolic tumor cells replacing endothelium of pulmonary vessel.
What do you see happening here?
The same process is illustrated in Fig. 11(a) where a large vascular sinus is shown containing many embolic cells from a bone sarcoma in man. The nuclei already show pycnosis, swelling, agglutination by fibrin, and are being surrounded by polymorphonuclear and lymphocytic cells. In (b) is another large blood-vessel from the same tumor with a giant cell among the red blood-cells. This, although of the "endothelial" type and not itself likely to invade other tissues, is of interest in showing that all types of cells may gain access to the blood stream.
FIG. 11.--(a) Embolus from bone sarcoma in man. Cells are of several types and illustrate early degenerative changes and phagocytosis. (b) Giant cell in blood-vessel in bone sarcoma.
That most of the small vascular emboli are derived from larger ones in the main vessel, and not from primary lymphatic involvement, is seen from such an extensive embolus as appears in Fig. 12 (No. 18343), a fairly frequent picture. A very large mass is found in one of the main pulmonary veins and many of its cells are degenerating, the nuclei are pycnotic, and some of the cells have been phagocyted.
FIG. 12--Larger tumor embolus in pulmonary artery.
Figure 13 shows a smaller group of cells surrounded by a thrombotic mass containing many polymorphonuclears, as would be expected in such a situation.
FIG. 13.-Polymorphonuclear cells surrounding a few embolic tumor cells; probably an early stage of thrombus formation.
It may only occasionally be seen that the cells break into the lymphatics and there grow freely, but it is shown in Fig. 14(No. 18307).
FIG. 14--Large embolus of tumor cells in perivascular lymph space; probably an extension from a vascular thrombus.
Not infrequently, as in tissues from human beings with tumors, multiple emboli are found in the vessels which may be densely crowded with cells, most of them small, and though hyperchromatic only with difficulty to be distinguished from lymphocytes--in fact, to make a differential diagnosis is very hazardous in spite of the absence of inflammation elsewhere in the section (Fig. 15).
FIG. 15.--Multiple emboli of small cells in pulmonary vessels, possibly tumor cells, but resembling lymphocytes.
Inspection of Table III shows that among the controls metastases and emboli were coincident only four times in twenty-one animals, or in 19 per cent., while among the massaged this occurred nine times in twenty-five animals, or in 36 per cent. of the cases. The average duration of life was the same in each case. There seems little doubt but that the massage has effected a wider distribution of the tumor even though it is impossible to decide in all the cases just what the ultimate fate of the scattered cells may be, whether they will die or succeed in establishing themselves in the vessel wall.
TABLE III
Crocker Fund No. 180
Total number metastases in controls = 23
Total number emboli in controls = 24
Total number metastases in massaged = 41
Total number emboli in massaged = 38
On the whole, the polyhedral-cell sarcomata (Crocker Fund No. 180 and Ehrlich mouse sarcoma) seemed just as apt to produce metastases as the carcinomata. In the spindle-cell tumors, metastases are apt to be scanty. This may be explained upon mechanical grounds, from the fact that the cells of most fibro-or spindle-cell sarcomata are more definitely intermingled with and attached to the surrounding connective tissue than in the case of the free-lying cells of the carcinomata. This sustains the view that anatomical relationships of the cells are important in determining metastases.
It would be incorrect, however, to assume that the mechanical factor is of so great importance in determining the ultimate production of a growing tumor as distinct from an embolus as the biological characteristics of the tumor itself. Examination of the chart shows that the correlation between the percentages of total metastases in controls and massaged animals is negative, that is, that those tumors which metastasize spontaneously in a high percentage do not show as great an increase after massage as do those in which spontaneous metastasis is low. For example, the Crocker Fund carcinoma No. 5 shows a smaller increase in its percentage of metastases than does the Flexner rat carcinoma. The same is true of the Ehrlich sarcoma, a strain in which Haaland also found a high percentage of spontaneous metastases; in fact, this writer reports approximately the same percentage of metastases in the twenty-three mice which he observed (60 per cent.) as were seen in the twenty-six animals used in this experiment (58 per cent.).
What is she claiming in her discussion here?
In these freely metastasizing highly vascular tumors the organism is evidently flooded with emboli before manipulation, and hence many tumor cells may be found in the pulmonary capillaries at all times. Less difference, therefore, can be detected following the massage.
What is the effect of massage in these cases, and why?
There can be no question under these circumstances that concomitant immunity has any influence on the prevention of appearance or growth of the metastases.
Is it clear what she means here?
CONCLUSIONS
1. Study of human material in many ways suggests, but does not finally prove, the importance of massage as a means of inducing metastasis of tumor cells. In animals, on the contrary, very gentle massage for a total period of from two to five minutes, distributed over a number of days, has been shown to set free numerous particles of tumor which form emboli in the lungs.
Is this the correct approach to take in studying the question?
Does the study show what she states that it shows?
2. Such emboli produce metastatic tumors in a variable proportion of instances, depending upon the growth activities of the tumor. Tumors which take in low percentages when implanted in the subcutaneous connective tissues give much fewer metastases than those of high virulence.
Is this consistent with what you would expect to see?
3. Carcinomata and also sarcomata of the loose polyhedral-cell type are easily generalized, but sarcomata of the compact spindle-cell variety are not influenced.
How do we know this from the information in her article?
4. The importance of avoiding diagnostic or operative manipulation of a tumor in man is obvious.
I agree it's a good idea in general. Does the evidence show that it's as obvious as Knox says it is?
No, it cannot. Massage of a solid tumor site should be avoided, but there is more to a person than a tumor site.
An old myth warned that massage could, by raising general circulation, promote metastasis since tumor cells travel through blood and lymph channels. We now recognize that movement and exercise raise circulation much more than a brief massage can, and that routine increases in circulation occur many times daily in response to metabolic demands of our tissues. In fact, physical activity usually is encouraged in people with cancer; there is no reason to discourage massage or some form of skilled touch. Massage is practiced widely at the Dana-Farber Cancer Institute, Memorial Sloan-Kettering, and growing numbers of hospitals around the country. Metastasis is not a concern; instead, patients and researchers report countless benefits.
BIBLIOGRAPHY
Bamberger and Paltauf: Wein klin. Wchnschr., 1899, vol. xii, p. 1100.
Benecke: Beitr. z. path. Anat. u. z. allg Path., 1890, vol. vii, p. 95.
Carmalt: Virchow's Arch. f. path. Anat., 1872, vol. lv, p. 481.
Crouzon: Bull. et mém. Soc. méd. d. hôp. de Par., 1920, vol. xlvi, p. 500.
Ernst: Beitr. z. Path. Anat., 1905, Supp., vol. vii, p. 29.
Ewing: Neoplastic Diseases, Philadelphia, 1920.
Gathmann: Ein Fall von allgeimeinen Karzinome des Knochensystems, Leipzig, 1902.
Gerster: New York M. J., 1885, vol. xli, p. 233.
Goldmann: Bruns Beitr. z. klin. Chir, 1897, vol. xviii, p 595.
Goldmann: Bruns Beitr. z. klin. Chir., 1911, vol. cxxii, p. 1.
Haaland: Berl. klin. Wchnschr., 1906, vol. xxxiv, p. 1126.
Handley: Arch. Radiol. and Electroth., 1919, vol. xxiv, p. 137.
Handley: Cancer of the Breast and Its Operative Treatment. London, 1906.
Handley: Lancet, 1907, vol. i, p. 927.
Iwasaki: J. Path. and Bacteriol., 1915-16, vol. xx, p. 85.
Jones and Rous: J. Exper. M., 1914, vol xx, p. 404.
Krasting: Ztschr. f. Krebsforsch., 1906, vol. iv, p. 315.
Lambert and Haynes: J. A. M. A., 1911, vol. vi, p. 791.
Murray: Seventh Scientific Report, Imperial Cancer Research Fund, London, 1921, p. 63.
Poirier et Charpy: Traite D'Anatomie Humaine, Paris, 1909, Tome II.
Rohdenburg: Proc. New York Path. Soc., 1920, n. s., vol. xx, p. 141.
Rous: J. A. M. A., 1913, vol. lx, p. 2021.
Sabin: The Harvey Lectures, 1915-16, Series xi, p. 124.
Schiedat: Ueber den Untergang maligner Geschwulstmetastasen in der Lung, Leber, und Lymphdrusen, Inaug.-Diss., Königsberg, 1908.
Schmidt: Die Verbreitungswege der Karzinome und die Beziehung generalisirter Sarkome zu den leukämischen Neubildungen, Jena, 1903.
Takahashi: J. Path. and Bacteriol., 1915-16, vol. xx, p. 1.
Tyzzer: J. M. Res., 1913, vol. xxiii, p. 309.
Van Raamsdonk: Nederlandsch Tijdschrift v. Geneeskunde, 1921, vol. i, p. 3355.
Virchow: Die Krankhaften Geschwulste, Band 2. Berlin, 1864-5.
Vogel: Virchow's Arch. f. path. Anat., 1891, vol. cxxv, p. 495.
Von Recklinghausen: Virchow's Arch. f. path. Anat., 1885, vol. c, p. 503.
Wood: J. A. M. A., 1919, vol. lxxiii, p. 764.
Zahn: Virchow's Arch. f. path. Anat., 1899, vol. cxvii, p. 30.
What have we learned from this discussion?
At the beginning of this post, I asked you the following questions:
Where did the idea that massage promotes metastasis, and therefore, we shouldn't offer massage to patients living with cancer, come from?
What is the current best practices recommendation for massaging someone with a history of cancer, and on what basis is that best practices recommendation formed?
Why is the idea that we shouldn't massage someone with a history of cancer, because it might promote metastasis, so persistent in the face of what we actually know?
Have your answers to them changed over the course of this discussion? If they have changed, then in what way have they done so?
What else did you learn during this discussion? Can you explain it to someone else now?
How relevant is this discussion to what we practice as MTs?
From Latin embolus (“piston”), from Ancient Greek ἔμβολος (embolos, “peg, stopper”).
embolus (plural emboli)
(pathology) An obstruction causing an embolism: a blood clot, air bubble or other matter carried by the blood stream and causing a blockage or occlusion of a blood vessel.
endothelium
Wiktionary "endothelium", accessed 27 December 2012
endothelium (plural endothelia)
(anatomy) A thin layer of flat epithelial cells that lines the heart, serous cavities, lymph vessels, and blood vessels.
In medicine, a fistula (/ˈfɪstjʊlə/;[1][2] pl. fistulas (/ˈfɪstjʊləz/), or fistulae (/ˈfɪstjʊli/ or /ˈfɪstjʊlaɪ/)) is an abnormal[3] connection or passageway between two epithelium-lined organs or vessels that normally do not connect.
A highly malignant epithelial tumour with a fulminant [quick, intense, and severe] clinical course, bizarre histologic appearance and poor prognosis [predicted outcome]; it is most common in the lung and thyroid, but is well-described in the endometrium, breast and elsewhere.
From Ancient Greek ὑπέρ (huper, “over”) + αἷμα (haima, “blood”).
hyperemia
excess of blood in a body part.
lymphocyte
Wiktionary "lymphocyte", accessed 29 December 2012
A lymphocyte is a type of white blood cell in the vertebrate immune system.
Under the microscope, lymphocytes can be divided into large lymphocytes and small lymphocytes. Large granular lymphocytes include natural killer cells (NK cells). Small lymphocytes consist of T cells and B cells.
A Krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site, classically the gastrointestinal tract, although it can arise in other tissues such as the breast. Gastric adenocarcinoma, especially at the pylorus, is the most common source. Krukenberg tumors are often (over 80%) found in both ovaries, consistent with its metastatic nature...
Pathogenesis
There has been debate over the exact mechanism of metastasis of the tumor cells from the stomach, appendix or colon to the ovaries. Classically it was thought that direct seeding across the abdominal cavity accounted for the spread of this tumor, but spread by way of the lymphatic is considered more likely.
Latin, from Ancient Greek μέλας (melas, “black, dark”) and -oma (“disease, morbidity”).
melanoma (plural melanomas or melanomata)
(oncology, pathology) A dark-pigmented, usually malignant tumor arising from a melanocyte and occurring most commonly in the skin.
metastasis
Wiktionary "metastasis", accessed 27 December 2012
From Late Latin, from Ancient Greek μετάστασις (metastasis, “removal, change”), from μεθίστημι (methistemi, “to remove, to change”)
Pronunciation
metastasis (plural metastases)
(medicine) The transference of a bodily function or disease to another part of the body, specifically the development of a secondary area of disease remote from the original site, as with some cancers.
obliteration
Wiktionary "obliteration", accessed 27 December 2012
Latin permeātus, participle of permeāre, meaning to pass through.
permeate (third-person singular simple present permeates, present participle permeating, simple past and past participle permeated)
To pass through the pores or interstices of; to penetrate and pass through without causing rupture or displacement; -- applied especially to fluids which pass through substances of loose texture; as, water permeates sand.
To enter and spread through; to pervade.
phagocytosis
Wikipedia "phagocytosis", accessed 29 December 2012
Phagocytosis (from Ancient Greek φαγεῖν (phagein) , meaning "to devour", κύτος, (kytos) , meaning "cell", and -osis, meaning "process") is the cellular process of engulfing solid particles by the cell membrane to form an internal phagosome by phagocytes and protists...Bacteria, dead tissue cells, and small mineral particles are all examples of objects that may be phagocytosed.
Wiktionary "phagocytosis", accessed 27 December 2012
From the German Phagocytosis; equivalent to phagocyte + -osis; compare the French phagocytose.
phagocytosis (countable and uncountable; plural phagocytoses)
(immunology, cytology) The process where a cell incorporates a particle by extending pseudopodia and drawing the particle into a vacuole of its cytoplasm.
Pyknosis (from Greek pyknono meaning "to thicken up, to close or to condense"), or karyopyknosis, is the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis[1] or apoptosis.[2] It is followed by karyorrhexis, or fragmentation of the nucleus.
polymorphonuclear cells
Wikipedia "Granulocyte", accessed 29 December 2012
Granulocytes are a category of white blood cells characterized by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes (PMN or PML) because of the varying shapes of the nucleus, which is usually lobed into three segments. In common parlance, the term polymorphonuclear leukocyte often refers specifically to neutrophil granulocytes, the most abundant of the granulocytes. Granulocytes or PMN are released from the bone marrow by the regulatory complement proteins.
Wiktionary "retrograde", accessed 27 December 2012
From Middle English < Latin retrogradus.
retrograde (comparative more retrograde, superlative most retrograde)
Directed backwards, retreating; reverting especially inferior state, declining; inverse, reverse; movement opposite to normal or intended motion, often circular motion.
serous (comparative more serous, superlative most serous)
(medicine) Containing, secreting, or resembling serum; watery; a fluid or discharge that is pale yellow and transparent, usually representing something of a benign nature. (This contrasts with the term sanguine, which means blood-tinged and usually harmful.)
Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when examined under a microscope. The tumors generally begin in layers of connective tissue such as that under the skin, between muscles, and surrounding organs, and will generally start as a small lump with inflammation that grows...Spindle cell sarcoma can develop for a variety of reasons, including genetic predisposition but it also may be caused by a combination of other factors including injury and inflammation in patients that are already thought to be predisposed to such tumors. Spindle cells are a naturally occurring part of the body's response to injury. In response to an injury, infection, or other immune response the connective tissues will begin dividing to heal the affected area, and if the tissue is predisposed to spindle cell cancer the high cellular turnover may result in a few becoming cancerous and forming a tumor.
(anatomy) Of, pertaining to, or containing vessels that conduct or circulate fluids, such as blood, lymph, or sap, through the body of an animal or plant.
Minimum scientific knowledge needed for this discussion
What anatomical system (or systems, depending on how you count them) do we and other complex animals (like dogs, cats, bears, elephants, and tigers) use for movement?
Easy question straight out of Anatomy 101, right? But did you ever think about how organisms or organism parts that don't have muscles and bones are still able to solve the challenge of moving from one place to another?
The Free Dictionary "ameboid movement", accessed 27 December 2012
movement like that of an ameba, accomplished by protrusion of cytoplasm of the cell.
Amoeboid movement is a crawling-like type of movement accomplished by protrusion of cytoplasm of the cell involving the formation of pseudopodia. The cytoplasm slides and forms a pseudopodium in front to move the cell forward. This type of movement has been linked to changes in action potential; the exact mechanism is still unknown. This type of movement is observed in amoeboids, slime molds and some protozoans, as well as some cells in humans such as leukocytes. Sarcomas, or cancers arising from connective tissue cells, are particularly adept at amoeboid movement, thus leading to their high rate of metastasis.
While several hypotheses have been proposed to explain the mechanism of amoeboid movement, the exact mechanism is still unknown.
What it comes down to, then, is that sarcomas and other cells use a method of movement very similar to the amoeba (or ameba: a one-celled animal-like microscopic organism) you see in this video:
As the definitions mentioned, in the video, you saw the cytoplasm slide to stick out (protrude) in the direction the amoeba moved.
Like the amoebas, individual cells in multi-cellular organisms (like us) can also move in a very similar way. Watch how nimbly responsive the human neutrophils (white blood cells) in this video are to the presence of a chemical attractant (this response is called chemotaxis):
As the Wikipedia definition mentioned, the ability of sarcomas to move in this way--although not yet fully explained--is thought to be a factor in their ability to metastasize aggressively.
The esophagus (oesophagus, commonly known as the gullet) is an organ in vertebrates which consists of a muscular tube through which food passes from the pharynx to the stomach. During swallowing, food passes from the mouth through the pharynx into the esophagus and travels via peristalsis to the stomach. The word esophagus is derived from the Latin œsophagus, which derives from the Greek word oisophagos, lit. "entrance for eating."...
Histology
The layers of the oesophagus are as follows:
mucosa
nonkeratinized stratified squamous epithelium: is rapidly turned over, and serves a protective effect due to the high volume transit of food, saliva and mucus.
lamina propria: sparse.
muscularis mucosae: smooth muscle
submucosa: Contains the mucous secreting glands (esophageal glands), and connective structures termed papillae.
muscularis externa (or "muscularis propria"): composition varies in different parts of the esophagus, to correspond with the conscious control over swallowing in the upper portions and the autonomic control in the lower portions:
From German Mitosis, from Ancient Greek μίτος (mitos, “thread”) + -osis, probably in reference to the thread-like chromatin seen during mitosis.
mitosis (plural mitoses)
(cytology) The division of a cell nucleus in which the genome is copied and separated into two identical halves. It is normally followed by cell division.
Occam's razor
Wikipedia "Occam's razor", accessed 29 December 2012
Occam's razor (also written as Ockham's razor, Latin lex parsimoniae) is the law of parsimony, economy, or succinctness. It is a principle stating that among competing hypotheses, the one that makes the fewest assumptions should be selected.
In animal tissue, stroma (from Greek στρῶμα, meaning “layer, bed, bed covering”) refers to the connective, supportive framework of a biological cell, tissue, or organ.
The stroma in animal tissue is contrasted with the parenchyma...Stromal cells are the non-tumor cells in tumors.
Parenchyma is the bulk of a substance. In animals, a parenchyma comprises the functional parts of an organ and in plants parenchyma is the ground tissue of nonwoody structures.
The term parenchyma is New Latin, f. Greek παρέγχυμα - parenkhuma, "visceral flesh", f. παρεγχεῖν - parenkhein, "to pour in" f. para-, "beside" + en-, "in" + khein, "to pour".[1]
The parenchyma are the functional parts of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, namely, the connective tissues.
In cancer, the parenchyma refers to the actual mutant cells of the single lineage, whereas the stroma is the surrounding connective tissue and associated cells that support it.
Early in development the mammalian embryo has three distinct layers: ectoderm (external layer), endoderm (internal layer) and in between those two layers the middle layer or mesoderm. The parenchyma of most organs is of ectodermal (brain, skin) or endodermal origin (lungs, gastrointestinal tract, liver, pancreas). The parenchyma of a few organs (spleen, kidneys, heart) is of mesodermal origin. The stroma of all organs is of mesodermal origin.
The peritoneum (pron.: /ˌpɛrɨtənˈiəm/) is the serous membrane that forms the lining of the abdominal cavity or the coelom—it covers most of the intra-abdominal (or coelomic) organs—in amniotes and some invertebrates (annelids, for instance). It is composed of a layer of mesothelium supported by a thin layer of connective tissue. The peritoneum both supports the abdominal organs and serves as a conduit for their blood and lymph vessels and nerves.
The abdominal cavity (the space bounded by the vertebrae, abdominal muscles, diaphragm and pelvic floor) should not be confused with the intraperitoneal space (located within the abdominal cavity, but wrapped in peritoneum). The structures within the intraperitoneal space are called "intraperitoneal" (e.g. the stomach), the structures in the abdominal cavity that are located behind the intraperitoneal space are called "retroperitoneal" (e.g. the kidneys), and those structures below the intraperitoneal space are called "subperitoneal" or "infraperitoneal" (e.g. the bladder).
Diane Jacobs, talking about dermoneuromodulation (DNM)--a practice that she has developed, and that we'll talk more about here later--answered that intellectual property question first, and better than I could have come up with off the top of my head.
When asked:
What's a good name for working top down and bottom up?
she answered:
Dermoneuromodulation.
It covers the manual territory from skin cell to self of self and leaves out the mesoderm entirely. It is not a copyright term.
Anyone can use it, to describe what they do, manually, if they want. This made-up word is not copyright. I give it away. Please take it. Use it to get away from words like "fascia" and "muscles" and "joints" and "bones" and "ligaments" and "tendons".
In the same way as Diane practices with regard to her development of DNM, I don't claim any restrictions on anyone's access to use of the term through copyright or ownership over the term "biopsychsocial massage (BPSM)".
I give it away to the community to use freely, in the same spirit of open access and Creative Commons licensing that POEM is founded on.
There is only one condition of usage--you cannot apply the term to something it is not, any more than someone can make a dog into a cat, just by calling it one.
In a similar way, you can't make non-BPSM practices into BPSM simply by slapping that label on them.
Diane explains that, although she gives the term away freely, that
It should contain only nervous system considerations though, because really, when push comes to shove, only the nervous system can respond (short term, OR, and ESPECIALLY, long term) to what we "do" to another person, manually. Of that I'm convinced.
Similarly, if you're not practicing biopsychosocial massage, the term does not apply to what you actually are doing.
You have every right under principles of freedom of conscience to reject classical Newtonian physics, for example, and to say that it does not apply to the work that you are doing. But that claim is inconsistent with the principles of BPSM, and so that inconsistency means, beyond the shadow of a doubt, that your practice is not a biopsychosocial massage practice. Which is fine in itself; you are entitled to practice any way you want to, subject to professional ethics and to regulations in your jurisdiction. All it really means is that you don't get to label it something that it is not--no more, no less.
There is a Cambodian saying that men are like diamonds and women are like silk--if you drop them in the mud, you can wash the diamond and it's as clean as it ever was, but the silk is stained forever.
«បុរសជាមាសទឹកដប់ ទោះធ្លាក់ចូលភក់ ហើយលើកមកវិញ ក៏នៅតែជាមាសទឹកដប់ដដែល តែនារីវិញ ប្រៀបបាននឹងកំណាត់សំពត់ស បើកាលណាធ្លាក់ចូលភក់ជ្រាំហើយ ទោះខំប្រឹងបោកគក់លាងសម្អាតយ៉ាងណា ក៏មិនដូចដើមដែរ» (courtesy of Frank Smith)
Let's put aside for the moment the blatant sexism in that proverb ("dropping them in the mud" is a metaphor for their being sexually active, and this is the classic embodiment of the double standard against women in so many traditional societies), and see if there is any useful imagery there for us to communicate a distinction in a totally different domain, without being insulting to more than half of the population.
The term "biopsychosocial massage" refers to massage practiced in an evidence-based, science-based, client-centered way, that understands health, wellness, and disease in terms of natural (not supernatural) processes in the material physical universe among biological, psychological, and sociocultural aspects of life, as well as their interactions and the emergent effects that arise from them.
Anyone who practices massage in this way is practicing BPSM.
If that term is consistently applied to only those practices, then it is a clean and brilliant diamond that clients and other massage stakeholders can use as a baseline to understand exactly what BPSM has to offer.
If the term is (figuratively) dropped in the mud by applying it to anything and everything, no matter whether or not it is consistent with the principles of BPSM, then--like the silk--it is stained forever, and it becomes useless for clients and other massage stakeholders to use as a guide to understand what BPSM has to offer.
So I give the terms "biopsychosocial massage" and "BPSM" to the community to use freely, on the one condition that they not be diluted by applying them as mere buzzwords to massage or other practices that are not massage practiced in an evidence-based, science-based, client-centered way, that understands health, wellness, and disease in terms of natural (not supernatural) processes in the material physical universe among biological, psychological, and sociocultural aspects of life, as well as their interactions and the emergent effects that arise from them.
(Not yet clear on what that means in actual practice? That's ok; there's a great deal of rich material there to explore in depth. We're going to spend some quality time connecting the dots, and translating them into what they mean for actual practice. I just want to get that general principle out there; now that it is, we can do some real work on establishing what it means in practice.)
So the answer to the question in the post title, "Who owns BPSM?" is: It is entrusted to the responsible and sustainable stewardship of the massage community.
cheers, to Diane Jacobs!
UPDATE, 18 November 2012, 10:57 AM PT:
Gayla Coughlin points out that some of my statements above, as written, are unclear in what they mean for actual practice, and might result in outcomes that I don't want.
I thank her for giving me the opportunity to correct my inaccuracies, and to get closer to my intended outcome.
I am thus taking out a Creative Commons license on biopsychosocial massage (BPSM), and here are the conditions attached to that license.
The particular form of the Creative Commons license that most suits my intent for this work is Attribution-ShareAlike CC BY-SA.
Their blurb explains:
This license lets others remix, tweak, and build upon your work even for commercial purposes, as long as they credit you and license their new creations under the identical terms. This license is often compared to “copyleft” free and open source software licenses. All new works based on yours will carry the same license, so any derivatives will also allow commercial use. This is the license used by Wikipedia, and is recommended for materials that would benefit from incorporating content from Wikipedia and similarly licensed projects.
What this means is that you can build on, develop, and grow biopsychosocial massage, but only on the condition that you share your work with the community in the same way ("license their new creations under the identical terms")--you cannot take the work that I and others have done on biopsychosocial massage, and trademark or copyright it for yourself. This license thus protects biopsychosocial massage for use by the entire community, rather than having someone seize it away from us in a proprietary way.
to Share — to copy, distribute and transmit the work
to Remix — to adapt the work
to make commercial use of the work
This means it is approved for Free Cultural Works
Under the following conditions:
Attribution — You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work).
Share Alike — If you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one.
With the understanding that:
Waiver — Any of the above conditions can be waived if you get permission from the copyright holder.
Public Domain — Where the work or any of its elements is in the public domain under applicable law, that status is in no way affected by the license.
Other Rights — In no way are any of the following rights affected by the license:
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Notice — For any reuse or distribution, you must make clear to others the license terms of this work. The best way to do this is with a link to this web page.
If my statements above sounded like I objected to commercial use on anyone's part, then that was due to my inaccuracy--I have no objection to anyone earning a living by teaching classes, writing books, or anything like that, as long as you honor the moral rights that attach to my Creative Commons licensing of biopsychosocial massage. And by "mere buzzwords", I was not objecting to using the term to market your works based on biopsychosocial massage. I specifically meant slapping the label on practices where it does not apply, in order to market something that is incompatible at its core with biopsychosocial massage.
By "moral rights", I specifically mean that I do not want anyone to use the label "biopsychosocial massage" to endorse practices that are anti-scientific or pseudoscientific, or that are not client-centered. Those violate the spirit of biopsychosocial massage, and are an infringement of my moral right to delineate a set of massage practices and theory that are consistent and compatible with modern science and with evidence in the material physical world.
If you respect that moral right, then you are free to build on and develop biopsychosocial massage for non-commercial or commercial uses, but you cannot take it away from the community by trademarking or copyrighting it for yourself.
So I believe that the conditions of this license protect my intent to release it to the responsible and sustainable stewardship of the community, at the same time that it protects the content from being distorted by misuse of the label to apply to something that contradicts the heart of biopsychosocial massage.
There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved.
Their many letters to each other over the years (preserved online in the Darwin Correspondence Project) stand as a testament to how much they thought, cared, and worried about each other.
The state of mind that I wish to preserve with respect to you, is to feel that while you are acting conscientiously & sincerely wishing, & trying to learn the truth, you cannot be wrong; but there are some reasons that force themselves upon me & prevent my being always able to give myself this comfort.
--Darwin Correspondence Project, Darwin, Emma to Darwin, Charles [c. Feb 1839] accessed 17 November 2012
She wants to feel secure that, if she (or he, or anyone) is really trying diligently and sincerely to learn what is true, that that effort guarantees that she cannot possibly be mistaken about what she is learning. The reason she is so concerned about this is that she was devoutly religious, and she knew that Charles had doubts about religion.
To be impossible to be wrong, through sheer effort and sincerity, is a lovely wish--and yet, in the same sentence, she admits to her beloved husband that even she herself cannot always keep up that belief.
She was right to be concerned about that issue--the history of science at that time in England contains many examples of geologists, paleontologists, biologists, and other scientists who set out on a journey to find evidence in the materialphysicalnatural world that proved the stories in the Bible to be literally true.
For example, if the story of Noah's Ark and the Flood were literally true, you would find evidence of it in the layers of rock in that part of the world. The scientists who set out to find it discovered that that evidence is not there, but other evidence, showing that other things happened, is indeed there.
The scientists who set out to demonstrate that the earth is literally only a bit more than 6000 years old demonstrated instead that they would have to reject all the other multiple sources of repeatable, verifiable evidence that showed the earth to be much older than that.
Darwin himself demonstrated that--rather than the Genesis creation story that species were created one time in their present and unchanging form--species actually change over time to better adapt to the environments they find themselves in.
When the evidence these scientists found contradicted what they wanted it to say about the literal truth of the Bible, they faced a test of their own moral character in deciding what to do next about that fact:
Some of the most solid scientific knowledge that we rely on every day came from people who had the courage to face the implications for their beliefs that the evidence presented them, and the integrity to not turn away from or deny the contradictions, but rather to engage with them.
To take a more contemporary example of that same spirit, this quotation from Julie Onofrio is, for me, the essence of the courageous engagement that we so urgently need to participate in if we really want to become a profession:
Having an open forum and getting some help in analyzing research is really needed in our profession. Yes, I have to say it disturbs me when the researchers say things like traditional modalities don't work--it's like a slap in the face to all who are doing energy work, or reiki, or Rolfing, and having results and success. It's very hard not to take it personally, but also to set emotions aside and remain in communication. But that is why I support it. I want to learn more and to support the profession in understanding research.
This willingness to remain engaged, even when it's difficult because it contradicts what we've been taught, is nothing short of admirable. Julie is showing the courage of facing difficult dilemmas that evidence presents us about how massage actually works, and she is actively engaging with that process, and in that, she is going the extra mile.
Like Emma and Charles Darwin, most MTs are good, decent, caring, and loving people, who want to understand the truth.
If just wanting it sincerely, and working hard at it, were enough by themselves to avoid error, most of us would be there already.
Sadly, in this material physical universe, those good intentions are not sufficient to help us to be correct.
The Board has undertaken a major revamp of policies and procedures, one which is causing a great deal of disruption among nationally certified MTs and continuing education providers.
Its CEO, Mike Williams, states that the purpose and effects of this change are
streamlined online processes, enhanced communications, and improved programs that elevate the profession and better serve the public.
Some of those changes may well have that effect--I am not personally nationally certified, and I have not yet examined the changes in depth as other MTs and bloggers such as Laura Allen have.
Q: Will NCBTMB continue to accept alternative courses like energy work, aromatherapy, animal massage, etc?
A: Yes. Massage therapy is part of the holistic profession as are several other modalities and techniques. NCB will continue to accept modalities and techniques that can be legally practiced by a massage therapist without another healthcare provider, (i.e., DC, MD, PT) present. As long as the technique or modality can be shown to be embedded in the lineage of massage, it will be accepted. This means that if the core information of the technique or modality can be referenced as a derivative of another technique or modality that is within the massage therapy scope of practice it will be accepted.
The argument over the relationship between massage and "energy work" is nothing new.
In the early 1990s, when I was in massage school, the NCBTMB was developing the first national certification exam--the National Certification Examination for Therapeutic Massage and Bodywork (NCETMB). Eventually, as a result of consumer pressure, they were forced to offer an energy-free alternative, the National Certification Examination for Therapeutic Massage and Bodywork (NCETM), for those MTs who did not want to be coerced into an anti-evidential belief system as the price of their professional training and licensure.
Although the argument is nothing new, there was a fresh opportunity to do something innovative here among the other disruptive changes--but NCBTMB did not take that opportunity.
Instead, they opted to permit teaching any information (which includes misinformationand malinformation) as approved continuing education, as long that that can be shown to be "embedded in the lineage of massage". Considering the long history of "massage myths", documented by Laura Allen (here and here), Lee Kalpin, Paul Ingraham, and many others, it is clear that just because an idea has been embedded in massage, even for a very long time, that does not mean the idea is correct.
NCBTMB had an opportunity to stand up for the principle that, in the therapeutic encounter, a professional should provide only validated warranted (justified or justifiable) high-quality information to the client.
They did not take the opportunity to stand up for that principle, and as a result of that decision, I cannot participate in their new process. I will not go on to apply for national certification as a practitioner, nor will I become an approved continuing education provider under those standards.
I regret those facts, as I consider them massive missed opportunities. But I cannot do it, because our first principles on these matters are so far apart as to be irreconcilable.
Don't misunderstand me here--I am positive that the NCBTMB members are well-intentioned, and that they wanted to do the right thing. I genuinely believe that they were attempting to have the best of both worlds for the benefit of all massage stakeholders, and to not hurt anyone's feelings.
I respect them as the kind, caring, motivated, passionate people that they clearly are.
If that, by itself, were enough to be right, as Emma Darwin wished, we would not have to have this very serious and difficult discussion.
But evidence doesn't work like that--you can't pick and choose which evidence you accept, and which you reject. Either you accept all the evidence, and you go courageously wherever those implications take you, or you just don't accept the evidence.
If they are going to accept massage's traditional explanation of "energy work"--no matter how many times that explanation has been shown by the evidence to be mythical--as validated approved continuing education with their official imprimatur, then they are not preparing MTs who are taught that explanation for modern translational science. Holding on to old ideas even after they have been disproven is an active obstacle to understanding these new developments.
The environment of massage is exhibiting selection pressures toward a type of massage that is integrated with validated high-quality information, and that prepares MTs for understanding advances in neuroscience, cognitive science, endocrinology, and pain science, and translating that understanding into clinical practices that are client-centered and effective.
As a direct response of those pressures, biopsychosocial massage is breaking off from the main lineage of massage to provide a new massage lineage that is fully consistent with those principles.
You can consider this the official birth announcement of a new lineage of massage.
Biopsychosocial massage (BPSM) is massage understood and practiced in a biopsychosocial model. It understands massage, health, wellness, and illness, and the knowledge bases underpinning those concepts in an evidence-based, natural (meaning, not supernatural), organic way that draws on what we know about biology and other natural sciences, psychology, sociocultural aspects of being human, and the emergent effects that arise from interactions among these various factors.
Psychosocial and cognitive approaches don't require that you become a clinical psychologist but that you have a broad concept of the influence of those factors and that you account for them in your encounters with your patients. Know the literature and be able to give management advice based on evidence. When people come to see you they want a plan. Have a plan that is defensible and that works toward their goals. Address concerns, fear avoidance, other stress, and unhelpful beliefs with compassion, understanding, empathy, and informed knowledge.
Understanding why people hurt is part of our professional responsibility and should change most everything we do on a daily basis away from traditional methods and towards methods defensible with modern science.--Jason Silvernail accessed 5 August 2011
An example of a biological factor in health could be increased cortisol in the bloodstream in response to chronic stress. The interaction of that biological factor with the increased daily stress in modern society would be an example of interactions among biological factors and sociocultural factors.
An example of a psychological factor in health could be a man who is less likely to seek professional treatment for pain than a woman is, because of his perception that stoically enduring pain is what men do in the society he grew up and lives in. The increased structural damage that can occur as a result of ignoring symptoms and delaying treatment is an example of the interactions among psychological factors and biological factors.
An example of a social factor in health could be the relative stigmatization of mental or behavioral illness, as compared to how more clearly structural conditions are regarded. This stigmatization can drive psychological conditions underground--say, for example, if someone did not get needed psychological treatment because they didn't want it to show up in their medical record. That would be an example of interactions among sociocultural factors and psychological factors.
Biopsychosocial massage is client-centered. That means that the psychological and social factors in the client's unique experience, as well as the universal biological factors we are all subject to, is the center of where we focus our attention and caring. It doesn't mean that we accept everything in someone else's experience is literally true. It does mean that we recognize that, for them it feels true, and for that reason alone, it is important in where we meet the client in the therapeutic encounter.
Biopsychosocial massage welcomes self-expression and the art of massage. It is clear, however, that sometimes our need for self-expression can come into conflict with clients' immediate healthcare needs, and--when that happens--we recognize that, in order to act as healthcare professionals, our ethical fiduciary duty is to put the clients' needs first, ahead of ours if necessary.
Biopsychosocial massage is wholistic, integrative, and evidence-based. That means that it does not draw upon supernatural explanations of mechanisms, and it builds upon foundational knowledge in the sciences to evaluate and validate the evidence for or against particular claims of effectiveness or mechanisms.
That means that we understand and practice it in a holistic, complementary, and integrative way, integrated with other domains of human knowledge and with the natural universe we find ourselves in, rather than silo'ed off in an alternative universe that denies material physical reality, and isolates us away from members of the client-centered biomedical healthcare team.
If a proposed explanation for an effect requires us, for example, to reject physics, as the explanation of "energy work" embedded in massage tradition does, then we face that contradiction head on, and we work to resolve it. If that means updating old beliefs in the light of new evidence, then that is the consequence of practicing biopsychosocial massage.
Michael Hamm is another contemporary example of courageous engagement, facing the evidence head-on and seeking to better understand. I'm paraphrasing his quote here, and I trust that he'll correct me if I've gotten it wrong. If I can find the original quote, I'll replace the paraphrase, but it was something to this effect:
I understand and accept that the traditional anatomical explanation behind craniosacral therapy doesn't hold up in light of the evidence. At the same time, I can't deny that I feel something when I am doing that work, something that I can't explain. I want to better understand what is going on when I do that work.
In the absence of clear evidence of what is exactly going on, this suspension of previous belief that has been disproven (and not yet replaced) is totally in line with the principles of BPSM. We don't have to always know everything; we just have to know what we do know, what we don't know, and how strong the evidence is behind our knowledge.
Since our encounters with clients will always run ahead of the available high-quality evidence, we don't limit ourselves only to what has been rigorously validated by studies and nothing else. We take our professional experience into account, and we actively seek to understand and incorporate the clients' preferences, whenever possible, in treatment. But in all these cases, in developing our approach to caring for the client, we remain clear on what is evidence, what is speculation, what is science, what is art, what is literal, and what is metaphor.
Understanding the material physical universe around us, and the centuries of cumulative human knowledge about that universe, give us powerful tools to draw upon. That understanding, combined with the caring that characterizes so many people who choose to go into massage as a career, is the heart of biopsychosocial massage.
Neil deGrasse Tyson sums it up almost perfectly:
I am driven by two main philosophies, know more today about the world than I knew yesterday. And lessen the suffering of others. You'd be surprised how far that gets you.
--Neil deGrasse Tyson
That quotation demonstrates the core of massage in a biopsychosocial model.
Over time, here at POEM, we will be following that evidence where it leads, and courageously engaging with the meanings that it shows for the practice of massage therapy. I expect intense, passionate, and fruitful discussions here over the next few years.
It's a lovely idea to think that there are no limits, and that we can have everything we want.
Certainly, a massive part of the US advertising industry is dedicated to selling that dream, precisely because it's such an appealing one. There is no shortage of people who will pay good money for the hope of living without limits.
In the realm of dreams and ideas, there may well be practically no limits to what we can imagine. But the material physical world imposes constraints, or limits, on what matter and energy are capable of, and what they cannot do.
We don't understand everything about why matter and energy behave the way they do, but over the centuries, we've observed them in enough different situations that we're pretty good at describing how they behave in those situations. It's very much like the situation with gravity--there are several different and mutually exclusive proposals for what gravity is, and why it works the way it does.
But we don't need to wait until those questions are decided to be able to predict how gravity will behave well enough for hundreds of thousands of airplanes worldwide to take off and land safely (for the most part) every day. We can predict its behavior so accurately that in 1970, when the Apollo 13 spacecraft suffered an explosion and fire on the way to the moon--an explosion which left the spacecraft badly damaged, and low on fuel to get back to earth, and oxygen for the astronauts to breathe--ground control was able, on the fly, to improvise a plan that took advantage of the Moon's gravitational field to act as a "gravity slingshot" to propel the spacecraft and all 3 astronauts safely back home.
The same is true for matter and energy. These behaviors are so reliable that their descriptions are called "laws of physics"--metaphorically, it's as if they "know" they have to "obey" certain "laws", so they always do so.
Of course, science never says anything is definitively, 100% certain. Some things are very uncertain, and they're likely to be revised as we learn more about them.
Other things, while not 100% certain, can be almost 99.9999% certain--so the effect is as though it's perfectly certain, even though there's always that tiny 0.0001% chance it will be changed someday in light of new evidence, if that new evidence ever does show up on the scene.
The limits of the material physical world around us have been observed, described, and discussed for thousands of years, and, because they are so reliable, you can see, many times, the same description of the consequences of those laws of physics being discovered independently in different cultures far away from each other in time and space as ancient Greece and medieval India.
One of those consequences, borne out time and time again by the behavior of matter and energy, has been described as the "principle of non-contradiction"--that, in the material physical universe, something cannot both exist and not-exist at the same time, or that something cannot be both true and false at the same time.
Did that statement make you think of Schrödinger's Cat? If so, then that's an excellent question you raise!
At first glance, it seems as though the cat might provide an exception to that rule: the cat is both dead and alive at the same time in this thought experiment.
It is typical of these cases that an indeterminacy originally restricted to the atomic domain becomes transformed into macroscopic indeterminacy, which can then be resolved by direct observation. That prevents us from so naively accepting as valid a "blurred model" for representing reality. In itself, it would not embody anything unclear or contradictory. There is a difference between a shaky or out-of-focus photograph and a snapshot of clouds and fog banks.--Wikipedia, "Schrödinger's cat" accessed 7 October 2012
—Erwin Schrödinger, Die gegenwärtige Situation in der Quantenmechanik (The present situation in quantum mechanics), Naturwissenschaften
(translated by John D. Trimmer in Proceedings of the American Philosophical Society)
When we're talking about the cat being simultaneously dead and alive, we are talking about a phenomenon at only the subatomic level of organization--what Schrödinger called "an indeterminacy originally restricted to the atomic domain".
When we're engaging with clients in a therapeutic encounter, however, we are not engaging solely on a subatomic level--we're engaging at many levels, up to and including the organism level: Schrödinger's "macroscopic" level.
To confuse the subatomic level of organization with the organism level is to make the same mistake as to assume that--because both sodium and chloride as elements are immediately and painfully deadly to humans at the atomic level, then their compound--salt--also shares those properties. (Although it is true that too much salt over too many years can wreck your health, but only in a very different way from elemental sodium and elemental chlorine.)
To confuse those levels of organization with each other is to "naively accept...as valid a 'blurred model' for representing reality". At the subatomic level, without an observer, we can use words or images like the previous one to imagine a cat that is simultaneously dead and alive.
In our macroscopic material physical reality, the moment an observer looks at the cat to see what is going on, the subatomic waveform collapses--it definitively commits to one state or the other, but not to both at the same time--and we have either a dead cat, or a live cat, but never both simultaneously.
Unlike the poor cat (sometimes), the law of non-contradiction is still alive and well at the organismal level of material physical reality, where our therapeutic encounters with our clients take place.
Our metaphorical "waveforms" also are forced to collapse in one direction ot the other at this point, but--unlike the electron--at least we get to choose which of the two mutually-exclusive options we commit ourselves to.
This principle shines a spotlight on where a number of the most heated battles in massage's culture wars are currently taking place.
We have to decide one way or the other on the following question--because of the law of non-contradiction, we can't just say "both", and hand-wave our way out of the profound philosophical and scientific questions it raises.
As a first principle, do we accept or reject the reality of the material physical universe?
We have the freedom to choose either answer, but--no matter how much we may want it--we can't have it both ways.
The answer we choose to that question will determine what we have to offer to clients, as well as how we relate to one another.
This, in turn, will set in motion what history will tell about how our future of massage turned out.
The problem with Orwellian talking heads, agitprop, faux news and Ballmer-like posturing is that they take away a foundation for a genuine movement to occur, because once we start denying facts, it's difficult to know when to stop.
We've got a lot of massive problems in massage--for example, at the same time that we have the chance for a place at the healthcare professional table under Obamacare, and that we say we want to be taken seriously as professional members of the healthcare team, our major credentialing organizations grant recognition to courses that take money for teaching claims like "body cells carry emotional memory", "craniosacral therapy moves skull bones", and "all past traumas are stored in the fascia".
Anyone who had a decent education in anatomy should be able to debunk those claims after the first day of the first class.
Yet our major professional organizations visibly sanction the teaching of claims like these and grant CE credit for them, at the same time we say we want to be real healthcare professionals.
Our walk doesn't match our talk, and the problem's not going to go away just because we refuse to face it.
If we refuse to face it and discuss it in a civil and professional way in an attempt to reach solutions, history's going to make us eat the decisions that others make for us about these problems.
And if we claim we want to incorporate the latest neuroscience findings into massage as a healthcare profession, and we start that process off by being Neurophysiology 101 denialists, how, exactly, is that supposed to work?
No one's denying the fact that this shift to accepting facts and material physical reality is going to cause a great deal of disruption and moral distress. The world has entirely shifted out from under us, and the old social contract that we were comfortably used to just does not work any more.
That fact is going to cause an unforeseeable amount of pain and distress, and we need to be extra kind to each other as a result.
But denying reality is not a sustainable choice anymore, and the only real question is whether we'll make the change in time to make use of these new opportunities, or whether our process will make us too late to accept the invitation, and we'll totally miss out.
Godin provides an aspirational ideal to assist in that process:
Transformational leaders don't start by denying the world around them. Instead, they describe a future they'd like to create instead.
We can't change the larger universal material physical reality that confronts us. What we can change is how we react to it, and that reaction--what we commit to--will sow the seeds for the future we want to create.
This morning, berry-picking took me in a most unexpected direction. On the way to looking up something else, I came across this:
Risks of consuming fermented foods
Alaska has witnessed a steady increase of cases of botulism since 1985. It has more cases of botulism than any other state in the United States of America. This is caused by the traditional Eskimo practice of allowing animal products such as whole fish, fish heads, walrus, sea lion, and whale flippers, beaver tails, seal oil, birds, etc., to ferment for an extended period of time before being consumed. The risk is exacerbated when a plastic container is used for this purpose instead of the old-fashioned, traditional method, a grass-lined hole, as the botulinum bacteria thrive in the anaerobic conditions created by the air-tight enclosure in plastic.--Wikipedia, "Fermentation: Risks of consuming fermented foods accessed 3 October 2012
Slightly off-topic, but interesting (I think!), in a berry-picking way, since we care about calling people by the names they want to be called: Did you notice that the paragraph used the word "Eskimo", and did that perhaps seem a little strange to you, because you've heard that you shouldn't use the term "Eskimo" when you mean the Inuit people, since the word is derogatory or pejorative or insulting?
You're not wrong, if you remember hearing that--the word "Eskimo" probably does, historically, have connotations that are belitting and insulting, and Native American and First Nations people have spoken out explicitly and firmly against the use of the word.
At the same time, there is no good inclusive replacement term that includes the Yup'ik peoples of Alaska--if you just say "Inuit" instead of "Eskimo", that's fine if you mean only Inuit people and no one else.
But if you mean Inuit people together with Yup'ik people, then there really isn't a well-known acceptable term that means both. So often, you will see Alaskan Native American (more so) and Canadian and Greenlandic First Nations and Inuit people (less so, or maybe even not at all, per Lee Kalpin's comment following this post) compromising, and using the term in order to be inclusive, despite the connotations that go along with the word.
What's happening in Alaska?
Alaska has witnessed a steady increase of cases of botulism since 1985. It has more cases of botulism than any other state in the United States of America.--Wikipedia, "Fermentation: Risks of consuming fermented foods accessed 3 October 2012
Botulism is a condition that paralyzes people and animals who eat food contaminated with botulin toxin, or who have an open wound through which the bacteria that produce the toxin (Clostridium botulinum) can enter the body. C. botulinum is an obligate anaerobic bacterium, meaning that it is obliged to grow in an environment without air--oxygen is deadly to it.
VERY IMPORTANT WARNING
This is why you absolutely never, under any conditions at all, give honey to babies under 1 year old--they don't yet have the immunity to fight off the bacteria that produce the toxin.
After 1 year of age and older, people can fight off the actual C. botulinum bacteria themselves, so the bacteria can't gain a foothold in their systems to begin pumping out the toxin.
But if the neurotoxic poison produced by that bacteria has already contaminated the food somehow--as opposed to the bacteria themselves--then that toxin can produce botulism in anyone.
Facial paralysis which spreads through the body is a typical symptom of botulism; very bad cases can actually cause death by paralyzing the muscles needed to breathe.
The 14-year-old in these pictures from Wikipedia show the paralysis that's typical of severe botulism. Although he appears dead, he was actually fully conscious, yet unable to move. His eyelids were drooping and his eyes were paralyzed, and the pupils were fixed and dilated. We hope he made a full recovery--Wikipedia doesn't tell us how his story turned out--but even if he did, it would require a long, slow, difficult path to rehabilitation.
"A 14-year-old with botulism. Note the bilateral total ophthalmoplegia [paralyzed eyes] with ptosis [drooping eyelids] in the left image and the dilated, fixed pupils in the right image. This child was fully conscious."
From 1950 to 1997, 105 confirmed outbreaks of foodborne botulism involving 214 persons occurred in Alaska (there were no confirmed cases during 1947-1949)...All cases occurred in Alaska Natives. The average annual incidence among Alaska Natives increased from 3.5 cases/100,000 population during 1950-1954 to 10.7 cases/100,000 during 1995-1997 [in other words, right about 3 times as many cases as you'd expect, based on history].--State of Alaska Public Health Epidemiology Report: Botulism in Alaska--A Guide for Physicians and Health Care Providers, 1998 Update accessed 3 October 2012
Source: State of Alaska Public Health Epidemiology Report: Botulism in Alaska--A Guide for Physicians and Health Care Providers, 1998 Update http://www.epi.hss.state.ak.us/pubs/botulism/fig_1.gif accessed 3 October 2012
They have a website where they promote cross-cultural understanding by presenting pictures and reports of daily life, festivals, and other events.
In a post, "The Best of the Whale", one of their writers, Bogdan, presents pictures from Ilisagvik Inupiaq Culture Camp, where elders and others share a meal of traditional foods.
Notice the blue plastic container, and the Ziploc plastic bags--we're going to get back to those in a moment.
The most desirable food served at the blanket toss festival is fermented whale meat and blubber (mikiaq). Elders particularly like mikiaq, because it is easy to chew. To keep the audience interested and at the site, mikiaq is served last, after all the other food items have been distributed.
Fermentation occurs when, under anaerobic conditions (reduced or no oxygen), you convert sugars (carbohydrates containing carbon [C], hydrogen [H], and oxygen [O] atoms as building blocks) like the kinds of glucose here:
nuna iterssaliorpâ: digs a hole in the ground, p. 180 (Old orthography)
qasaerdlâq: a seal which has been put by whole and left to ferment, p. 211 (Old orthography)
Back in the old days, fermenting the mikiaq was accomplished by digging a hole in the ground, and leaving it there for as long as it took the process to occur naturally.
Nowadays, just like most of the rest of us reading this, circumpolar peoples have access to modern conveniences like the blue container and the Ziploc bags you saw in the photo from the festival.
Plastic bags, containers, and utensils, no matter how bad they are for the environment, have some convenient qualities that make them so widespread in food preparation. One of those properties is the ability to keep food fresh for longer periods of time.
It does this by sealing the food away from exposure to air that would cause it to decay faster. In other words, it promotes an anaerobic environment.
And that's where the connection to the increased cases of botulism lies.
This is caused by the traditional Eskimo practice of allowing animal products such as whole fish, fish heads, walrus, sea lion, and whale flippers, beaver tails, seal oil, birds, etc., to ferment for an extended period of time before being consumed. The risk is exacerbated when a plastic container is used for this purpose instead of the old-fashioned, traditional method, a grass-lined hole, as the botulinum bacteria thrive in the anaerobic conditions created by the air-tight enclosure in plastic.--Wikipedia, "Fermentation: Risks of consuming fermented foods accessed 3 October 2012
Fermentation in a grass-lined hole, while still an anaerobic process, is less efficient at keeping the oxygen out, since air will circulate in and out of the hole and between the blades of grass. The C. botulinum bacteria have to overcome the deadly oxygen in that air, if they are going to establish a strong enough foothold to produce enough neurotoxin to make the mikiaq dangerous to the people who eat it.
A plastic container, on the other hand, does a much better job of keeping out the oxygen. Less oxygen in the container means a more welcoming environment for C. botulinum, where they can start to churn out neurotoxin.
As plastics have come into wider and wider use in the general population, and as they have made their way to more remote areas, where the convenience appealed to people, they took the existing risk of botulism, and--by providing a better anaerobic environment--sent the cases of botulism much higher than had been the case when mikiaq used to be fermented in the traditional grass-lined hole.
What all this means is that--contrary to what you may have heard--evidence-based practice does not mean that you have to give up traditional practices just because they are traditional, and adopt modern practices just because they are modern.
It means that instead of a top-down simplistic rule-based approach (either "Old = Good! New = Bad!": the "Argument from antiquity" fallacy, or the other way around, "Old = Bad! New = Good!": the "Argument from modernity" fallacy), we take a bottom-up approach of examining the evidence itself, and then deriving more nuanced and accurate rules that we can turn around and apply. Which, in turn, means that everything, traditional and modern alike, gets examined to find out:
what works in the way it claims to,
what doesn't work in the way it claims to, and
the mechanisms for why that is the case.
Once we better understand the answers to those questions, we can better decide which practices fit better into our client-centered model of service, and why they do so. This example was a perfect demonstration of how sometimes evidence supports the traditional practice as objectively better, as measured on the basis of outcomes (number of cases of botulism), than the modern practice.
Denying reality is not a sustainable choice anymore, and the only real question is whether we'll make the change in time to make use of these new opportunities, or whether our process will make us too late to accept the invitation, and we'll totally miss out.
Godin provides an aspirational ideal to assist in that process:
Transformational leaders don't start by denying the world around them. Instead, they describe a future they'd like to create instead.
We can't change the larger universal material physical reality that confronts us. What we can change is how we react to it, and that reaction--what we commit to--will sow the seeds for the future we want to create.
What we are going to do in this course is this: for validated scientific anatomical knowledge, we are going to create and make openly available anatomical knowledge organization templates (KOTs), based on the original Anatomical Knowledge Organization Templates developed by my teacher, Cornelius Rosse.
anatomy: gross, histology, microscopic, comparative ==> levels of analysis
physiology: how do the anatomical parts actually work, how do their structure and orientation and location influence what they can do, how body systems work together, and how they influence each other ==> regulation, emergent properties, systems science
can we always separate those questions? mouse prostate example
but most of the things we are dealing with will be much more straightforward than that. when it's harder, we'll flag it.
============================================
How do we study anatomy and physiology?
Anatomy is easier to visualize with our eyes, with dissections, and instruments like microscopes: "learning to see what we're trying to understand".
Physiology is processes: we need to know how to approach more complicated visualizations
what we can see and touch on dissections: gross anatomy (and you can imagine the jokes punning off of "gross")--formalin smell
histology: study of tissues, built up of cells (cytology)--uses microscope in order to understand how tissues can work (physiology), we have to understand structure of cells on microscopic level (anatomy)
neural tissue made up of neural cells can support memory because their structure can carry electric signal. other types of tissue cannot because they cannot carry electrical signal. so if you see claims that body cells carry emotional memory, you have to choose between that and histology. What we see inside the cell, how the cells are arranged in relationship to each other, how much space is between the cells--all of these material physical anatomical aspects of cells influence what physiological functions the tissues made up of those cells are able to carry out
microscopic anatomy: looking at cells and tissues under a microscope/histology
cytology
we are getting into levels of analysis here
two resources that we will draw upon here as necessary are embryology (developmental biology) and comparative anatomy--together, they are called evo-devo
you won't be tested on these subjects. but the knowledge they contain will support our reasoning about the anatomy that we *are* responsible for knowing, so we'll take them into account in order to more fully understand the subject.
comparative anatomy: why do humans have 1 prostate and mice have 5? why do bears have anucleate cells? the answers to these questions provide valuable information about human anatomy, in a (metaphorically) similar way to how learning a foreign language can help us better understand why our native language does things in the way it does. this is one of the bases for comparative medicine: MIN
model organism examples: in-depth understanding
levels of analysis:
(smaller ones we haven't talked about yet)
cellular anatomy and histology
gross anatomy
(larger ones we haven't talked about yet)
notice that the levels of analysis are very different from each other. MIN
this will become important when we look at how people try to talk about massage and quantum physics. when we get to that, it will be your job to decide whether what they say makes sense. To do that, you need to be aware of what it means to talk about different levels of analysis, and how structures and functions of the same thing at one level of analysis can be very different from structures and functions of that same thing at a different level of analysis
look at one level of analysis, and understand how it leads to supporting structure and function at the next level of analysis
"system by system and connect the dots"
anatomy: how do we use our "eyes, microscope, and imagination" to develop a good, solid, and in-depth understanding of anatomy and physiology that will support us in providing high-quality, client-centered care?
physiology: how do we use our "anatomy knowledge, logical thinking, and basic knowledge of chemistry and cell biology" to develop a good, solid, and in-depth understanding of anatomy and physiology that will support us in providing high-quality, client-centered care?
"anatomy is very visual"
you can't understand how body parts and systems work (physiology) if you don't understand the anatomy where physiology happens (and, later, pathology--abnormal functioning)
logical thinking: "a lot of physiology is connecting dots, step-by-step" -- how these parts work together
basic chemistry and cell biology that you need to understand to make physiology make sense: plausibility
"Complementary principles
Function cannot occur without structure
Functions are often dictated by form" MIN
you need physiology to stay alive. dead bodies can have anatomy.
"interconnected: you need both to stay alive, and you need a good knowledge of both to be successful" this is a bridge or an obstacle to integration
"What is life"
Always an interesting question to ponder
Schrödinger's paradox--order comes from disorder
Socrates--objects are a reminisce of previous objects
Hooke & Schwann cell theory (more later)"
when we say we practice massage because we want to make a difference in people's lives, what is the implicit knowledge that we are drawing upon to ground what we say
many viewpoints on this: philosophical, Socrates, "The Republic", the Cave--we're shadows of former objects
science: order comes from disorder==?chemical reactions, cells, movements of molecules and ions into and out of cells--"there needs to be some kind of chaos on the molecular level for us to stay alive"
chaos: sperm in water, hormones rather than vasculature in fish
cell theory (what is a theory), then modern cell theory==life cannot occur
without cell, cell is functional unit that drives life--this is why viruses are not considered alive to understand what it means to be alive, we need to understand levels of organization--at what level does life actually begin?
we have to talk about matter--matter is anything that takes up space and has mass--some kind of physical presence
atoms--smallest simplest forms of matter in nature, can't see, have various behaviors--examples C, H, O,N, K+, various behaviors
molecules/compounds--combinations of atoms; glucose, protein, lipid, hormone, chemical message, structural protein like cell membrane--is a protein or a sugar alive? they don't have a metabolism
organelles--look at a cell, as we will next week, see distinct parts, nucleus, ER, Golgi apparatus, ribosome: sacs with enzymes that drive biochemical reactions--can a fuel factory be alive? no, separate and not organized
cells--organized organelles, start to see life take place--nucleus, DNA inside can start to use all other organelles for chemical reactions--this is where life begins, at cellular level--political implications, pro-life,
pro-choice
tissues--put cells of different varieties into organized tissues
organs--organized tissues of different types
organ systems--11
organism
population systems--how long can you go without any human contact? how well
could you survive on your own? we need each other to survive. everyone is
different in levels of need, but we need each other
fractal: population system, analogies with organ systems and with cells
image of levels of organization
where does life begin? at cellular level
"Interrelationships of organ systems
cells rely on organ systems to maintain life
cells drive the function of organ systems
the interrelationship of these two concepts drive life"
MIN
we have to go all way down to cellular level for good understanding of
physiology
good part of physiology n day 2 day level is keeping cells alive: example
respiration
bridge to pathophysiology
what are the pathological changes that occur at the cellular level--what drives disease to happen? what cellular changes occur that make the tissue go awry?
cells drive live; most of our physiology is spent keeping life going at the cellular level
"Requirements for life
boundaries
movement
responsiveness
digestion
metabolism
excretion
reproduction
growth and change
what organ systems drive each of these functions?"
physical boundaries; borders between tissues, organs, cells, internal ve
external--skin is major outer boundary, connective tissue serve as boundaries inside
why do we need movement? get meal, look at animals who don't get blood clots in hibernation—musculoskeletal responsiveness to changes--changes in environment (int or ext) occur all the time--we need to be able to adapt to them, and if we can't, we will die--
nervous, endocrine--homeostasis later
digestion--breaking food down into simplest building blocks so that we can absorb it and make use of it--1, eat the food 2, break it down 3, absorb it 4, excrete it what don't absorb when finished--if you understand these concepts, then you can understand diseases like Crohn's disease or diarrhea
metabolism--what is metabolism? burning calories? digesting food? only 1/2 the equation--metabolism is about all chemical reactions that occur in body--certain systems help regulate, nervous, endocrine--life-giving chemical reactions occur within cell itself--building up and breaking down molecules in the chemical reactions that sustain life
excretion--where there is metabolism, there has to be excretion, because there are waste products left over--CO2, for example. respiratory system--urinary system, kidneys, waste filtering organs--without kidneys, won't live very long--skin can sweat out some waste, digestion--kidneys biggest one,
cells constantly excreting waste products (lymph)--constantly producing waste products, must be removed--remove organic waste products
reproduction--permits continuity of life--extremely important organ system--we are reproducing faster than we are dying off--panda bears--poaching is a problem--big mammals in general take a long time to reach sexual maturity, so vulnerable to poaching--when are we readily physically to reproduce--puberty--8-13 years after we're born. physiologically, not
psychologically. we as a species not threatened enough to get us to point where repro is big issue for us.
growth and evolution--growth necessary for life to take place. compare birth. grow to self-sustainable, mature organism. evolution as well--evolution is just change--adapting to environments and surviving--we need to evolve to changes in environment as well--and animal or plant that does not evolve will not survive--
"survival needs
oxygen
nutrition
water
normal temperature
pressure"
oxygen big part of making ATP and cellular energy--big metabolic deal
nutrition--calories, fuel, making energy, protein to make plasma proteins, need structure--protein deficient people look very wasted away because digesting own muscles--vitamins, minerals, proteins fats for energy storage, structural purposes, driving metabolic reactions
water main transport medium, bulk of body is water--most people have ~40 liters of water in blood and tissues, helps drive chemical reactions, thrermoregulator
temp--is big, 98.6, but without temp, metabolism going to go nuts, ability to circ O2, metabolism, going to die if hindered --too high or too low
pressure--why pressure? important for breathing, transport--no one ever talks about BP in good context, always hypertension--BP necessary because without it, how would we circ blood, filter nutrients out of capillaries into tissues
respiration--must be enough pressure to drive oxygen out of air, into our tissues,
"homeostasis
maintenance of a stable internal environment, i.e., balance
dynamic equilibrium--we operate around various set points that fluctuate when exposed to various stimuli
if we fail to return back to our normal set points, disease and sickness ensue"
what constitutes life, what life is, homeostasis is a big, not well-understood concept
we strive for on day to day basis==
phys balance
dyn equil. -- 98.6F your temp goes up and down, all during the day
go outside in cold weather, your body tem goes down
body water levels maintained by monitoring sodium levels, if osmolarity drops below certain point, body salts get too high, we get dehydrated, and need to get fluid back into our system--
certain set points that we need to survive=-homeostasis maintains balance around those certain set points how do we know what those points are?
always fluctuate around set points, but if we fluctuate too far, and don't get back to the set point, that's some form of disease
98.6F--temp goes down in cold air, so physiological mechanisms protect us, and help us reverse the drop in temp
body water level by monitoring sodium levels, osmolarity drops, salt too high, dehydrate, have to get water back in system
how do we know what a "normal" body temperature is, what a normal sodium level is, set points correspond to lab values among other things
nutrient levels, metabolism, what organ system is responsible for constant monitoring of this?
the most important system in human body is nervous system. some systems self-regulate to some degree, but regulation of body systems is the nervous system's job
if we fail to return back to normal set points, sickness occur--BP goes up and down, sit, stand, walk run move around, BP up to meet increased demand on body, as we age, BP tends to rise. we have mechanism that tend to compensate, but if those mechanisms fail, that's high BP
if our own systems fail, that's where medical intervention comes in
if body can't regulate BP, pills prescribed--bring in Olney at this point--if we need help to get physiology back to normal
maintain balance through feedback loops
"maintenance of homeostasis
always exposed to internal and external stimuli
requires constant monitoring by the nervous system
main form of regulation is through feedback loops
two loops: negative and positive feedback"
some organs do kind of self-regulate, like pancreas self-regulates insulin secretion, for most part in general, nervous system regulates everything
when nervous system detects changes in body, it needs to "figure out" (metaphorically) how to return to normal.
uses feedback loops
"negative feedback loop
three components: receptor, control center, effecter organ"
loop: something circular
negative most common regulatory mechanism in human body
receptor, control center, effecter organ
neg feedback begins with receptor, specialized cell or group of cells in nervous system, whose job is to detect changes--stimuli--stimulus, singular--factors that upset or disrupt physiology, changes in environment
all these receptors do is constantly wait for a stimulus
receptor detects a change, generate impulses to control center--main
control center in body is brain--central nervous system is brain and spinal
cord. receptors pick up on changes, send info about changes to control
center. control center (CNS) "develops" "plan of attack" for bringing situation back to normal (xref with innervation)
communicates with effector organ. effector organ carries out right response to get us back to normal set point, receptors, control center, effectors
shut off, because continuing to correct would over compensate, and take us in the wrong direction (tacking in a sailboat)
example: classical example: thermostat. cold air comes into house, thermostat set at 70F. 0F air comes in for 3 minutes. cold air came in, now house temperature of kitchen lower. as a result, something picks up on this, thermostat is receptor as well. temp to 65F, thermostat detects.
thermostat sends signal to heater, turns heater on. heater starts pouring out heat, only until gets back to 70F. then shuts off so house doesn't get too hot above 70F
overheating compared to hyperthyroidism. if we don't shut off response, that could kill us, oversecrete hormone while trying to get back to normal.
BP: say BP goes up from 120/80, 145/86 mm Hg. we need to get it back down.
if exercising, ok, but don't want it that high at rest. there is a baroreceptor (baro means heavy or pressure). the baro receptors are in carotid arteries in neck in carotid sinuses, sensitive only to changes in BP
BP up, baroreceptors detect it, communicate with control center. control center in this case is brainstem. effector organs in this system are heart and blood vessels (arteries).
heart rate will respond to high BP by going down, output of blood volume pumped out will go down. are we going to increase dilate or constrict decrease diameter of arteries down HR and dilated arteries with less pressure will make BP go down dilated arteries easier blood flow, then entire response shuts off at reset to 120.80
what happens if gets too low? pass out, bc brain not getting enough oxygen
carotid sinus massage
vasovagal syncope response to high-stress situations.
orthostatic hypotension
negative feedback is most common regulatory mechanism in body why is it called negative?
negates or changes a stimulus--back to normal and then shut off when get back to set point.
"positive feedback loop
can be life-threatening"
this is what we call an amplifying cycle
positive feedback is good but can be life-threatening as well, because it just keeps getting greater and greater and greater over time--there is no automatic shutoff valve, like there is on a negative feedback system
like neg, has to be some kind of stimulus that triggers it to begin
here's the difference
example childbirth--once uterus stretches to certain point, it starts generating active nervous potentials to brain, and the brain is going to respond by releasing hormone called oxytocin
uterus got stretch, stimulus is baby in this situation that stretched uterus, oxytocin makes smooth muscle of uterus start to contract, it's a labor contraction, what happens with labor contractions over time, they get worse, more intense, they do not get more pleasant over time, intensity goes up, and the amount of time in between the contractions goes down.
start out 20-30 minutes apart, by the time it's time to give birth, they're about 20-30 seconds apart. so there's a stimulus that activated the response, but the response continued to enhance, it got greater and greater and greater over time.
the only thing that's going to shut off a positive feedback loop is when the stimulus--in this case, the baby--is removed from the body
removal of stimulus turns off positive feedback
fever another example, this can be threatening,
you have pathogen within you
big initial spike in body temp, maintain high body temp, or slowly rises,
if body temp gets too high, it can kill you
if body temp gets too high, requires medical intervention, or it will kill you
my fever story
blood clotting mechanisms is pos feedback mechanism--too many clots stuck in circulation can impeded blood flow to essential organism somewhere
my blood clotting story
problem is, if too intense of stick around too long, can threaten our life, but it is a kind of feedback loop
you have the stimulus (stretch receptors in uterus picking up on presence of baby_
communicating with control center of brain on this
the difference here is the brain is continuing to amplify an amplify and amplify, making the response greater and greater and greater until the stimulus is gone
neg--stimulus triggers response to get back to certain set point, then stops--you can't get rid of body temperature or body water, can['t get rid of stimulus itself
pos & neg fb--we use these to maintain and regulate homeostasis--physiological balance
this is what our everyday life revolves around--keeping ourselves balanced, keeping all our set points in check to keep ourselves alive
topics and concepts you need to understand
understand difference in levels of analysis, claims about "balance", what has been shown and what hasn't, semantics
Psychosocial and cognitive approaches don't require that you become a clinical psychologist but that you have a broad concept of the influence of those factors and that you account for them in your encounters with your patients. Know the literature and be able to give management advice based on evidence. When people come to see you they want a plan. Have a plan that is defensible and that works toward their goals. Address concerns, fear avoidance, other stress, and unhelpful beliefs with compassion, understanding, empathy, and informed knowledge.
Understanding why people hurt is part of our professional responsibility and should change most everything we do on a daily basis away from traditional methods and towards methods defensible with modern science.--Jason Silvernail accessed 5 August 2011
Since I'm advocating massage in a biopsychosocial model, it's my job to connect the dots and explain what I mean by that.
A biopsychosocial model of health and illness is one that takes into account the role of biology (and other sciences), psychological factors, and sociocultural factors, as well as the interactions among those different factors, in seeking to understand what health and illness really are.
An example of a biological factor in health could be increased cortisol in the bloodstream in response to chronic stress. The interaction of that biological factor with the increased daily stress in modern society would be an example of interactions among biological factors and sociocultural factors.
An example of a psychological factor in health could be a man who is less likely to seek professional treatment for pain than a woman is, because of his perception that stoically enduring pain is what men do in the society he grew up and lives in. The increased structural damage that can occur as a result of ignoring symptoms and delaying treatment is an example of the interactions among psychological factors and biological factors.
An example of a social factor in health could be the relative stigmatization of mental or behavioral illness, as compared to how more clearly structural conditions are regarded. This stigmatization can drive psychological conditions underground--say, for example, if someone did not get needed psychological treatment because they didn't want it to show up in their medical record. That would be an example of interactions among sociocultural factors and psychological factors.
Biopsychosocial massage is client-centered. That means that the psychological and social factors in the client's unique experience, as well as the universal biological factors we are all subject to, is the center of where we focus our attention and caring. It doesn't mean that we accept everything in someone else's experience is literally true. It does mean that we recognize that, for them it feels true, and for that reason alone, it is important in where we meet the client in the therapeutic encounter.
Biopsychosocial massage welcomes self-expression and the art of massage. It is clear, however, that sometimes our need for self-expression can come into conflict with clients' immediate healthcare needs, and--when that happens--we recognize that, in order to act as healthcare professionals, our ethical fiduciary duty is to put the clients' needs first, ahead of ours if necessary.
Biopsychosocial massage is wholistic, integrative, and evidence-based. That means that it does not draw upon supernatural explanations of mechanisms, and it builds upon foundational knowledge in the sciences to evaluate and validate the evidence for or against particular claims of effectiveness or mechanisms.
Since our encounters with clients will always run ahead of the available high-quality evidence, we don't limit ourselves only to what has been rigorously validated by studies and nothing else. We take our professional experience into account, and we actively seek to understand and incorporate the clients' preferences, whenever possible, in treatment. But in all these cases, in developing our approach to caring for the client, we remain clear on what is evidence, what is speculation, what is science, what is art, what is literal, and what is metaphor.
Understanding the material physical universe around us, and the centuries of cumulative human knowledge about that universe, give us powerful tools to draw upon. That understanding, combined with the caring that characterizes so many people who choose to go into massage as a career, is the heart of biopsychosocial massage.
Neil deGrasse Tyson sums it up almost perfectly:
I am driven by two main philosophies, know more today about the world than I knew yesterday. And lessen the suffering of others. You'd be surprised how far that gets you.
--Neil deGrasse Tyson
That quotation demonstrates the core of massage in a biopsychosocial model.
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The practice of medicine is an art, not a trade; a calling, not a business; a calling in which your heart will be exercised equally with your head.
William Osler
Mind your boundaries and be tolerant of the uncertainty that is clinical practice.
Jason Silvernail
Absolutely you need to think carefully about the ideas you pass along to your patients. Are they accurate scientifically? Do they serve the patient's best interest given your responsibility to them?
Jason Silvernail
Being a teacher is a little bit like being a psychotherapist. It turns out that you get much more than you give. I am eternally grateful for what I have been given.
