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Translational healthcare

Massage in a biopsychosocial model

[reposted from Massage in a biopsychosocial model (#29/31)]

 

 


Psychosocial and cognitive approaches don't require that you become a clinical psychologist but that you have a broad concept of the influence of those factors and that you account for them in your encounters with your patients. Know the literature and be able to give management advice based on evidence. When people come to see you they want a plan. Have a plan that is defensible and that works toward their goals. Address concerns, fear avoidance, other stress, and unhelpful beliefs with compassion, understanding, empathy, and informed knowledge.

Understanding why people hurt is part of our professional responsibility and should change most everything we do on a daily basis away from traditional methods and towards methods defensible with modern science.--Jason Silvernail accessed 5 August 2011

 

Since I'm advocating massage in a biopsychosocial model, it's my job to connect the dots and explain what I mean by that.

A biopsychosocial model of health and illness is one that takes into account the role of biology (and other sciences), psychological factors, and sociocultural factors, as well as the interactions among those different factors, in seeking to understand what health and illness really are.

An example of a biological factor in health could be increased cortisol in the bloodstream in response to chronic stress. The interaction of that biological factor with the increased daily stress in modern society would be an example of interactions among biological factors and sociocultural factors.

An example of a psychological factor in health could be a man who is less likely to seek professional treatment for pain than a woman is, because of his perception that stoically enduring pain is what men do in the society he grew up and lives in. The increased structural damage that can occur as a result of ignoring symptoms and delaying treatment is an example of the interactions among psychological factors and biological factors.

An example of a social factor in health could be the relative stigmatization of mental or behavioral illness, as compared to how more clearly structural conditions are regarded. This stigmatization can drive psychological conditions underground--say, for example, if someone did not get needed psychological treatment because they didn't want it to show up in their medical record. That would be an example of interactions among sociocultural factors and psychological factors.

Biopsychosocial massage is client-centered. That means that the psychological and social factors in the client's unique experience, as well as the universal biological factors we are all subject to, is the center of where we focus our attention and caring. It doesn't mean that we accept everything in someone else's experience is literally true. It does mean that we recognize that, for them it feels true, and for that reason alone, it is important in where we meet the client in the therapeutic encounter.

Biopsychosocial massage welcomes self-expression and the art of massage. It is clear, however, that sometimes our need for self-expression can come into conflict with clients' immediate healthcare needs, and--when that happens--we recognize that, in order to act as healthcare professionals, our ethical fiduciary duty is to put the clients' needs first, ahead of ours if necessary.

Biopsychosocial massage is wholistic, integrative, and evidence-based. That means that it does not draw upon supernatural explanations of mechanisms, and it builds upon foundational knowledge in the sciences to evaluate and validate the evidence for or against particular claims of effectiveness or mechanisms.

Since our encounters with clients will always run ahead of the available high-quality evidence, we don't limit ourselves only to what has been rigorously validated by studies and nothing else. We take our professional experience into account, and we actively seek to understand and incorporate the clients' preferences, whenever possible, in treatment. But in all these cases, in developing our approach to caring for the client, we remain clear on what is evidence, what is speculation, what is science, what is art, what is literal, and what is metaphor.

Understanding the material physical universe around us, and the centuries of cumulative human knowledge about that universe, give us powerful tools to draw upon. That understanding, combined with the caring that characterizes so many people who choose to go into massage as a career, is the heart of biopsychosocial massage.

Neil deGrasse Tyson sums it up almost perfectly:

I am driven by two main philosophies, know more today about the world than I knew yesterday. And lessen the suffering of others. You'd be surprised how far that gets you.

--Neil deGrasse Tyson

 

That quotation demonstrates the core of massage in a biopsychosocial model.


Source: http://healthskills.files.wordpress.com/2008/10/biopsychosocial.jpg accessed 7 August 2012

Sometimes evidence shows that the old ways actually are the best

While cherry-picking--the act of suppressing evidence that doesn't support our own particular biases--is something to be avoided, berry-picking, on the other hand--carrying out our searches for information in a way that is not strictly linear and that incorporates cognitive questions, by allowing those searches to evolve and change in response to what we initially come across--is not only to be encouraged, but can be absolutely delightful in the unexpected directions it leads us.

This morning, berry-picking took me in a most unexpected direction. On the way to looking up something else, I came across this:

Risks of consuming fermented foods

Alaska has witnessed a steady increase of cases of botulism since 1985. It has more cases of botulism than any other state in the United States of America. This is caused by the traditional Eskimo practice of allowing animal products such as whole fish, fish heads, walrus, sea lion, and whale flippers, beaver tails, seal oil, birds, etc., to ferment for an extended period of time before being consumed. The risk is exacerbated when a plastic container is used for this purpose instead of the old-fashioned, traditional method, a grass-lined hole, as the botulinum bacteria thrive in the anaerobic conditions created by the air-tight enclosure in plastic.--Wikipedia, "Fermentation: Risks of consuming fermented foods accessed 3 October 2012

 


Slightly off-topic, but interesting (I think!), in a berry-picking way, since we care about calling people by the names they want to be called: Did you notice that the paragraph used the word "Eskimo", and did that perhaps seem a little strange to you, because you've heard that you shouldn't use the term "Eskimo" when you mean the Inuit people, since the word is derogatory or pejorative or insulting?

You're not wrong, if you remember hearing that--the word "Eskimo" probably does, historically, have connotations that are belitting and insulting, and Native American and First Nations people have spoken out explicitly and firmly against the use of the word.

At the same time, there is no good inclusive replacement term that includes the Yup'ik peoples of Alaska--if you just say "Inuit" instead of "Eskimo", that's fine if you mean only Inuit people and no one else.

But if you mean Inuit people together with Yup'ik people, then there really isn't a well-known acceptable term that means both. So often, you will see Alaskan Native American (more so) and Canadian and Greenlandic First Nations and Inuit people (less so, or maybe even not at all, per Lee Kalpin's comment following this post) compromising, and using the term in order to be inclusive, despite the connotations that go along with the word.

 


What's happening in Alaska?

Alaska has witnessed a steady increase of cases of botulism since 1985. It has more cases of botulism than any other state in the United States of America.--Wikipedia, "Fermentation: Risks of consuming fermented foods accessed 3 October 2012

 

Botulism is a condition that paralyzes people and animals who eat food contaminated with botulin toxin, or who have an open wound through which the bacteria that produce the toxin (Clostridium botulinum) can enter the body. C. botulinum is an obligate anaerobic bacterium, meaning that it is obliged to grow in an environment without air--oxygen is deadly to it.

VERY IMPORTANT WARNING

This is why you absolutely never, under any conditions at all, give honey to babies under 1 year old--they don't yet have the immunity to fight off the bacteria that produce the toxin.

After 1 year of age and older, people can fight off the actual C. botulinum bacteria themselves, so the bacteria can't gain a foothold in their systems to begin pumping out the toxin.

But if the neurotoxic poison produced by that bacteria has already contaminated the food somehow--as opposed to the bacteria themselves--then that toxin can produce botulism in anyone.

 

Facial paralysis which spreads through the body is a typical symptom of botulism; very bad cases can actually cause death by paralyzing the muscles needed to breathe.

The 14-year-old in these pictures from Wikipedia show the paralysis that's typical of severe botulism. Although he appears dead, he was actually fully conscious, yet unable to move. His eyelids were drooping and his eyes were paralyzed, and the pupils were fixed and dilated. We hope he made a full recovery--Wikipedia doesn't tell us how his story turned out--but even if he did, it would require a long, slow, difficult path to rehabilitation.

 

"A 14-year-old with botulism. Note the bilateral total ophthalmoplegia [paralyzed eyes] with ptosis [drooping eyelids] in the left image and the dilated, fixed pupils in the right image. This child was fully conscious."

Source: http://upload.wikimedia.org/wikipedia/commons/b/b4/Botulism1and2.JPG accessed 3 October 2012

 

From 1950 to 1997, 105 confirmed outbreaks of foodborne botulism involving 214 persons occurred in Alaska (there were no confirmed cases during 1947-1949)...All cases occurred in Alaska Natives. The average annual incidence among Alaska Natives increased from 3.5 cases/100,000 population during 1950-1954 to 10.7 cases/100,000 during 1995-1997 [in other words, right about 3 times as many cases as you'd expect, based on history].--State of Alaska Public Health Epidemiology Report: Botulism in Alaska--A Guide for Physicians and Health Care Providers, 1998 Update accessed 3 October 2012

 

Source: State of Alaska Public Health Epidemiology Report: Botulism in Alaska--A Guide for Physicians and Health Care Providers, 1998 Update http://www.epi.hss.state.ak.us/pubs/botulism/fig_1.gif accessed 3 October 2012

 

The Rose Urban Rural Exchange, in its own words, "aims to strengthen relationships between urban and rural Alaskans by building mutual respect and understanding, and fostering a statewide sense of community through cross-cultural immersion.".

They have a website where they promote cross-cultural understanding by presenting pictures and reports of daily life, festivals, and other events.

In a post, "The Best of the Whale", one of their writers, Bogdan, presents pictures from Ilisagvik Inupiaq Culture Camp, where elders and others share a meal of traditional foods.

Notice the blue plastic container, and the Ziploc plastic bags--we're going to get back to those in a moment.

 

Source: http://ecci-2012.s3.amazonaws.com/thumbs/20120814_ecc_grp_iic_awi_70_502ab33f88f97.JPG.poster.jpg accessed 3 October 2012

 

Bogdan describes the scene:

The most desirable food served at the blanket toss festival is fermented whale meat and blubber (mikiaq). Elders particularly like mikiaq, because it is easy to chew. To keep the audience interested and at the site, mikiaq is served last, after all the other food items have been distributed.

 

Mikiaq is

raw whale blubber that has been left to soak and ferment in the whale's blood.

 

Fermentation occurs when, under anaerobic conditions (reduced or no oxygen), you convert sugars (carbohydrates containing carbon [C], hydrogen [H], and oxygen [O] atoms as building blocks) like the kinds of glucose here:

Source: http://upload.wikimedia.org/wikipedia/commons/0/06/DL-Glucose.svg accessed 3 October 2012

 

 

 

into ethanol, the kind of alcohol in drinks such as beer, wine, and spirits, a process which rearranges those atoms into this arrangement:

Source: http://upload.wikimedia.org/wikipedia/commons/3/37/Ethanol-2D-flat.png accessed 3 October 2012

 

Greenlandic to English Dictionary

nuna iterssaliorpâ: digs a hole in the ground, p. 180 (Old orthography)

qasaerdlâq: a seal which has been put by whole and left to ferment, p. 211 (Old orthography)

 

Back in the old days, fermenting the mikiaq was accomplished by digging a hole in the ground, and leaving it there for as long as it took the process to occur naturally.

Nowadays, just like most of the rest of us reading this, circumpolar peoples have access to modern conveniences like the blue container and the Ziploc bags you saw in the photo from the festival.

Plastic bags, containers, and utensils, no matter how bad they are for the environment, have some convenient qualities that make them so widespread in food preparation. One of those properties is the ability to keep food fresh for longer periods of time.

It does this by sealing the food away from exposure to air that would cause it to decay faster. In other words, it promotes an anaerobic environment.

And that's where the connection to the increased cases of botulism lies.

This is caused by the traditional Eskimo practice of allowing animal products such as whole fish, fish heads, walrus, sea lion, and whale flippers, beaver tails, seal oil, birds, etc., to ferment for an extended period of time before being consumed. The risk is exacerbated when a plastic container is used for this purpose instead of the old-fashioned, traditional method, a grass-lined hole, as the botulinum bacteria thrive in the anaerobic conditions created by the air-tight enclosure in plastic.--Wikipedia, "Fermentation: Risks of consuming fermented foods accessed 3 October 2012

 

Fermentation in a grass-lined hole, while still an anaerobic process, is less efficient at keeping the oxygen out, since air will circulate in and out of the hole and between the blades of grass. The C. botulinum bacteria have to overcome the deadly oxygen in that air, if they are going to establish a strong enough foothold to produce enough neurotoxin to make the mikiaq dangerous to the people who eat it.

A plastic container, on the other hand, does a much better job of keeping out the oxygen. Less oxygen in the container means a more welcoming environment for C. botulinum, where they can start to churn out neurotoxin.

As plastics have come into wider and wider use in the general population, and as they have made their way to more remote areas, where the convenience appealed to people, they took the existing risk of botulism, and--by providing a better anaerobic environment--sent the cases of botulism much higher than had been the case when mikiaq used to be fermented in the traditional grass-lined hole.

 


What all this means is that--contrary to what you may have heard--evidence-based practice does not mean that you have to give up traditional practices just because they are traditional, and adopt modern practices just because they are modern.

It means that instead of a top-down simplistic rule-based approach (either "Old = Good! New = Bad!": the "Argument from antiquity" fallacy, or the other way around, "Old = Bad! New = Good!": the "Argument from modernity" fallacy), we take a bottom-up approach of examining the evidence itself, and then deriving more nuanced and accurate rules that we can turn around and apply. Which, in turn, means that everything, traditional and modern alike, gets examined to find out:

  • what works in the way it claims to,
  • what doesn't work in the way it claims to, and
  • the mechanisms for why that is the case.

 

Once we better understand the answers to those questions, we can better decide which practices fit better into our client-centered model of service, and why they do so. This example was a perfect demonstration of how sometimes evidence supports the traditional practice as objectively better, as measured on the basis of outcomes (number of cases of botulism), than the modern practice.

 

Source: http://upload.wikimedia.org/wikipedia/commons/e/e2/PSM_V37_D324_Greenland_eskimo.jpg accessed 3 October 2012

Massage in a biopsychosocial model (#29/31)

Psychosocial and cognitive approaches don't require that you become a clinical psychologist but that you have a broad concept of the influence of those factors and that you account for them in your encounters with your patients. Know the literature and be able to give management advice based on evidence. When people come to see you they want a plan. Have a plan that is defensible and that works toward their goals. Address concerns, fear avoidance, other stress, and unhelpful beliefs with compassion, understanding, empathy, and informed knowledge.

Understanding why people hurt is part of our professional responsibility and should change most everything we do on a daily basis away from traditional methods and towards methods defensible with modern science.--Jason Silvernail accessed 5 August 2011

 

Since I'm advocating massage in a biopsychosocial model, it's my job to connect the dots and explain what I mean by that.

A biopsychosocial model of health and illness is one that takes into account the role of biology (and other sciences), psychological factors, and sociocultural factors, as well as the interactions among those different factors, in seeking to understand what health and illness really are.

An example of a biological factor in health could be increased cortisol in the bloodstream in response to chronic stress. The interaction of that biological factor with the increased daily stress in modern society would be an example of interactions among biological factors and sociocultural factors.

An example of a psychological factor in health could be a man who is less likely to seek professional treatment for pain than a woman is, because of his perception that stoically enduring pain is what men do in the society he grew up and lives in. The increased structural damage that can occur as a result of ignoring symptoms and delaying treatment is an example of the interactions among psychological factors and biological factors.

An example of a social factor in health could be the relative stigmatization of mental or behavioral illness, as compared to how more clearly structural conditions are regarded. This stigmatization can drive psychological conditions underground--say, for example, if someone did not get needed psychological treatment because they didn't want it to show up in their medical record. That would be an example of interactions among sociocultural factors and psychological factors.

Biopsychosocial massage is client-centered. That means that the psychological and social factors in the client's unique experience, as well as the universal biological factors we are all subject to, is the center of where we focus our attention and caring. It doesn't mean that we accept everything in someone else's experience is literally true. It does mean that we recognize that, for them it feels true, and for that reason alone, it is important in where we meet the client in the therapeutic encounter.

Biopsychosocial massage welcomes self-expression and the art of massage. It is clear, however, that sometimes our need for self-expression can come into conflict with clients' immediate healthcare needs, and--when that happens--we recognize that, in order to act as healthcare professionals, our ethical fiduciary duty is to put the clients' needs first, ahead of ours if necessary.

Biopsychosocial massage is wholistic, integrative, and evidence-based. That means that it does not draw upon supernatural explanations of mechanisms, and it builds upon foundational knowledge in the sciences to evaluate and validate the evidence for or against particular claims of effectiveness or mechanisms.

Since our encounters with clients will always run ahead of the available high-quality evidence, we don't limit ourselves only to what has been rigorously validated by studies and nothing else. We take our professional experience into account, and we actively seek to understand and incorporate the clients' preferences, whenever possible, in treatment. But in all these cases, in developing our approach to caring for the client, we remain clear on what is evidence, what is speculation, what is science, what is art, what is literal, and what is metaphor.

Understanding the material physical universe around us, and the centuries of cumulative human knowledge about that universe, give us powerful tools to draw upon. That understanding, combined with the caring that characterizes so many people who choose to go into massage as a career, is the heart of biopsychosocial massage.

Neil deGrasse Tyson sums it up almost perfectly:

I am driven by two main philosophies, know more today about the world than I knew yesterday. And lessen the suffering of others. You'd be surprised how far that gets you.

--Neil deGrasse Tyson

 

That quotation demonstrates the core of massage in a biopsychosocial model.


Source: http://healthskills.files.wordpress.com/2008/10/biopsychosocial.jpg accessed 7 August 2012

Looking into the abyss (#26/31)

It's not easy to face the realization of having been misled.

And the misleading does not have to be intentional; it could have been done with the best intentions in the world.

But those good intentions don't change the facts that, as a result, the student is launched into real-life practice operating with poor information, is bringing misinformation into the relationship with the client, and is being publicly evaluated on the basis of that misinformation by other potential partners in a unified healthcare team.

It could have happened to any of us--the field of massage is notorious for promoting teachers out of the ranks of students who have simply passed the class they're now expected to teach. Biomedical physicians have nothing on massage when it comes to "See one, do one, teach one".

No blame, no shame: one set out to create that situation; it just evolved that way, undirected. And there was an unspoken social contract that allowed it to continue, because the need for teachers was so high.

But the social contract has changed out from under us, and the current situation is no longer sustainable in light of the responsibilities expected of healthcare professionals.

Ralph Stephens names the problem as the very first one in his list of the educational "seven deadly sins":

Standardizing the number of hours or the curriculum content (ELAP) will not improve educational outcomes as long as our massage educational institutions are allowed to:

  1. Employ unqualified instructors.

...

Two things are needed to "heal" the problem, money and moral conviction. ABMP, AMTA and FSMTB must be persuaded to give substantial and ongoing financial support to COMTA and AFMTE to assist them with their respective missions. COMTA because we need a strong accrediting agency dedicated to the field of massage therapy. That is the natural place for educational standards to live. AFMTE because their Teacher Education Standards Project (TESP) is the trail that the entire education sector must follow if we are to truly "elevate" the profession from the sad state in which it currently exists.

These organizations also need to take a public stand - an unequivocal position - that the operational practices listed in the "Seven Deadly Sins" are no longer acceptable in the massage therapy field; that we expect better from our schools and programs. They may not have the force of law, but such moral courage on the part of community leaders, consistently stated, can and will instigate a change in institutional behavior.

 

Stephens is right about going forward--but what about all the students, practitioners, and teachers who are coming to grips with the fact that much of what they were taught is exaggerated, counterfactual, or simply wrong?

It takes a great deal of courage on their part to stare unflinching into that abyss, and to engage with what's needed to collect, assimilate, organize, and share good information.

The upheaval and disruption in the process is causing a great deal of moral distress and pain in people who are re-evaluating where they are, and how far away they are from where they need to be.

One thing that they do not have to worry about here is being blamed for having been taught wrong.

The policy here is, "no blame, no shame": it is not someone's fault that they did not get the education they deserve, and if they are trying to fix that situation, they deserve--and will have--our support in that journey.

The Buddhist concept of samma-vaca--"right speech"--is a useful guide to discourse here at POEM.

It's often summarized as, "Is it true? Is it kind? Is it necessary?".

We'll examine those questions in a slightly different order than they're usually posed.

"Is it true?": The standard at POEM is that we will not pass along misinformation here.

Massage stakeholders can depend on POEM for accurate information about massage.

If someone is making a factual error, it's ok to correct that error civilly and professionally. That means focusing on the facts, not on the person--no personal attacks, just connecting the dots on what the facts are.

Not everything is a matter of fact, of course--there is no scientific answer to the question "Is chocolate or vanilla better?"--and interpretations, creativity, and imagination are welcome topics for discussion, as long as active misinformation doesn't ride along.

"Is it necessary?": There is a wide consensus that something is rotten in the state of massage education, so yes, having a portal to the shared body of biomedical knowledge that members of a unified and client-centered healthcare professional team all draw upon to varying degrees is an absolutely necessary--and as-yet unmet--niche that POEM is being developed to fill.

"Is it kind?": Absolutely: everyone who participates here can expect to be treated kindly. Kindness does not mean letting misinformation go uncorrected; it means that misinformation will be corrected in a civil, professional, and kind manner, without attacking the person.

When someone does not have access to good and high-quality information, because of gaps in their education, the kind and considerate thing to do is to offer them a bridge to obtain that information.

Giving them an opportunity to correct themselves is far kinder than leaving them--and their clients--to the consequences of misinformation.

We're in really deep waters here, as a result of a number of historical, social, political, and cultural factors all coming together and synergizing.

But if POEM has any say at all in the matter, then we will get through these difficulties, because we'll support each other in learning and growing along the way.

 

Source: http://www.education.noaa.gov/images/article_ocean_floor_2.jpg accessed 26 August 2012

What is biopsychosocial massage?

Several other people have contributed greatly to my thoughts on the topic of biopsychosocial massage, and a really profound discussion along those lines is currently going on in a social media group that I'm a part of.

I'm not going to quote those other people directly here, because they were speaking in a private group, and I respect their privacy. This lack of quotations, however, should not be interpreted to mean that I fail to recognize the influence that others have had, and continue to have, on these ideas that I'm developing here. I'll be very happy to acknowledge and cite those discussions that are not explicitly private.

I am very grateful for everyone who has mentored me and contributed to my professional development, and who continue to do so to this day.

I promise you that I will pay it forward.

 

 


Biopsychosocial massage is the practice of massage in a way that builds bridges to working on a unified team with biomedical healthcare providers by participating in the shared knowledge base of biological, psychological, and sociocultural factors that influence health and illness.

That means that practitioners of biopsychosocial massage practice massage in a way that is compatible with the current state of the evidence. We don't create obstacles to being part of a unified team by making counterfactual and unsupportable claims about how massage works.

It facilitates our professional development as healthcare providers by putting the client at the center of knowledge and information. One of the most stressful situations in life is illness--by committing to a shared knowledge base and sending a unified message to the client as the rest of the team does, we do not add to the client's cognitive burden and stress load at a particularly difficult time by forcing them to do the additional work to try to sort out conflicting alternative and contradictory messages.

It means that we are honest about what we know, and what we don't know. That includes a responsibility to develop basic scientific literacy and critical thinking, in order to ground our perceptions and experiences in the larger context of what we know about the material physical universe around us. The "bio" aspect of "biopsychosocial" actually draws on many other natural sciences than just biology, and understanding the cohesive integration of the knowledge generated by all of those disciplines is crucial to an honest evaluation of what we really know about the world around us.

It means that we always need to be aware, at a very general level, of the fact that psychosocial factors can influence the state of a person's health, for better or for worse.

It means that we need to understand the difference between being a supportive layperson versus practicing psychotherapy, which--among other things--means listening supportively without giving advice or interpreting meaning.

It means we should know what the signs are that indicate someone is in greater psychological distress than we ourselves are equipped to help them with, and to have a plan for how to reach out to the larger psychotherapeutic community, either to assist them in getting help, or in our need for supervision or mentoring in processing what our clients bring to us.

It means that--no matter how we regard those particular sociocultural factors, for better or for worse--we recognize the profound effects those factors can have on the health status of our clients, and, to the best of our ability, we take those factors into account when we try to understand our clients' experiences.

It means that we recognize that the available research evidence will always lag behind immediate needs for information in the clinic, and so evidence-based practice will always remain an ideal or a goal as a result of that fact. Working practically in real life in the meantime, it means that we practice in a way that is based on the evidence, if available, and if evidence is not available then we at least practice in a way that is consistent with the larger body of knowledge about how the physical universe works.

It means that we put our responsibility to our clients above our attachment to particular ideas and claims--if claims about massage or other related topics repeatedly fail validation tests, we accept that fact, make our peace with it, and move on to what we do actually know that can be of benefit to our clients.

It does not mean at all that the subjective experience of meaning-making, or joy, or humor, or spontaneous feeling are off-limits--it simply means that we remain clear, to ourselves and to everyone else, on the differences between objective and subjective, mind-independent and mind-dependent, universal and unique, literal and metaphorical/allegorical, and fact and interpretation.

It does not mean at all that we are not open to new ideas--it simply means that, for the sake of our clients, we expect the advocates of those ideas to do the work of connecting the dots and showing how those ideas truly lead to positive outcomes for our clients, before we go on to regard those ideas and claims to actually have the status of validated knowledge.


Source: http://healthskills.files.wordpress.com/2008/10/biopsychosocial.jpg accessed 7 August 2012

 

 

 

Foundational concepts: Abstraction/abstract and concrete

"Abstract" has two important meanings in research literacy.

One meaning is a short summary of a research article; we'll explore the abstracts of research articles in more depth in Chapter 13: Reading massage research--The Abstract.

The meaning that is important to us here and now is "abstract" as a property, or quality, or aspect of things after they have gone through a process of abstraction. "Concrete" is the opposite of "abstract" in this sense.

The process of abstraction means concentrating on what things have in common with each other, and classifying them on that basis.

Wikipedia has a good example, proceeding from more abstract to less abstract (and, in that way, proceeding from less concrete to more concrete):

Thus something as simple as a newspaper might be specified to six levels, as in Douglas Hofstadter's illustration of that ambiguity, with a progression from abstract to concrete in Gödel, Escher, Bach (1979):

  (1) a publication

    (2) a newspaper

      (3) The San Francisco Chronicle

        (4) the May 18 edition of the The San Francisco Chronicle

          (5) my copy of the May 18 edition of the The San Francisco Chronicle

            (6) my copy of the May 18 edition of the The San Francisco Chronicle as it was when I first picked it up (as contrasted with my copy as it was a few days later: in my fireplace, burning)

 

In a healthcare context, you could abstract from "Miguel's kidney"--a concrete, tangible object that you can actually hold in your hand--to the class (like a set) of human kidneys, of which Miguel's kidney is one of many.

Source: http://keyhealthcareblog.com/wp-content/uploads/2011/09/kidney-transplant-small.jpg accessed 18 May 2012

 

All of those human kidneys have a lot of structural and functional things in common with Miguel's kidney, which makes them all members of the abstract class "human kidney".

Although they have lots of differences too, it's the similarities we focus on in the process of abstraction--they are "kidney-bean" shaped; they are composed of a medulla and a cortex, they are located retroperitoneally in the abdominal cavity, and they are part of the human urinary system, among many other qualities they share.

So while you can hold Miguel's concrete kidney in your hand, and it may have unique qualities of its own--larger or smaller than usual, perhaps suffering from some kind of condition or disease--it also shares common or universal qualities with other member of the class of "human kidney".

We can continue to perform abstraction: if we take away the description requirement that it has to be in a human, we can abstract from Miguel's kidney to the abstract class "Mammalian kidney", whose members have many of the same qualities as each other.

Source: A walrus kidney, one member of the abstract class "Mammalian kidney", http://cvmbsresearch.files.wordpress.com/2010/06/2091.jpg accessed 18 May 2012

 

If we take away the requirement that it has to be located retroperitoneally in the abdominal cavity, and that it has to be kidney-bean-shaped, then we can bring in the fishes whose kidneys migrate during develoment to a position near their heads. Then we can abstract even further, all the way from Miguel's kidney to the abstract class "Vertebrate kidney".

Source: Fish kidneys, members of the abstract class "Vertebrate kidneys", http://australianmuseum.net.au/Uploads/Images/13770/dissection8_big.jpg accessed 18 May 2012

 

The members of this class also have many of the same qualities, although they have fewer of those, and are more different from each other, than the members of the class "Mammalian kidney". In turn, members of the class "Mammalian kidney" are more diverse than are the members of the class "Human kidney".

The more abstract a class is, the less all the members have in common with each other, and the more they vary from one another. Still, they all have a certain foundational similarity that is the basis for their membership in the class.

What is the purpose of this kind of classification and abstraction? Based on their similarity, we can talk about things that are universal ("kidneys in animals filter urine"), rather than being constrained to only the concrete ("Miguel's kidney filters urine") and nothing more.

So, since research studies are carried out on individuals, rather than being able to say only "massage reduces anxiety in 25 selected elderly residents of a long-term care facility", we can--if the research is carried out in a methodologically sound fashion--use those similarities that connect members of a class ("elderly residents of a long-term care facility") to use that abstraction to reason about the validity of applying those results to other members of that class.

That abstraction is at the heart of how we can carry out a study on a sampling of a population, and--if the study's methods are sound--use the outcomes from that sample population to reason that, because the sample has things in common with the larger abstract class, that we would expect to see those results in the larger class, or population.

It makes possible the change from "this treatment worked on this one small group of people and that's all we can say" to "because this treatment worked on this one small group of people, we expect it will work in a similar fashion on the larger population that this small group has characteristics in common with".

Puffin Abstraction

Source: Puffin Abstraction, photographed by Tim Ford. A tufted puffin at the Point Defiance Zoo and Aquarium in Tacoma, Washington, USA. accessed 17 May 2012

 

 

Why POEM's developing an e-Book on evolutionary biology for MTs

One of POEM's main raisons d'être (reasons for being/existing) is to provide solid and validated support for learning and exploration in massage.

Because all of us are curious and engaged, and because we care about the world around us, we naturally try to explore further, and sometimes we take a leap into the unknown to try to figure it out.

There's absolutely nothing wrong with that--it's one of the core things that makes us human. I want to continue to encourage that exploration, because out of it will come new knowledge that will eventually benefit our clients/patients, and make us better MTs through improving our understanding.

It's easier to give updated information to someone who's already exploring than it is to try to spark curiosity in someone who, for whatever reason, doesn't demonstrate it spontaneously.

So when I see someone making a leap into the unknown, but--through no fault of their own--going down the wrong path because they're missing a crucial piece of information, that tells me that there's a need for that information, and that it therefore falls within POEM's mission to provide that information on a universal level.

If you've been shamed and shut down before by others for not knowing something, then having misinformation corrected by someone else, even by a caring teacher, may feel similar to that previous situation.

That's understandable, but that's not the intent here. A better analogy is that you're exploring a trail through an unfamiliar forest, and you come to a fork in the trail. Not knowing which branch will lead to your goal, you guess which one to take. Then, on your journey, you meet someone who has traveled that path before, and--while not knowing your exact destination--at least knows the area you are traveling toward.

For that person to tell you "that trail over there goes where you want to go; this one doesn't" isn't a criticism--it's encouragement to keep going to where you want to be, in a way that makes it more likely for you to get there.

Source: http://matadornetwork.com/wp-content/uploads/2011/05/20090923-wanderlust.jpg accessed 5 April 2012

 

In keeping with that mission, when the emphasis is on correcting what appears to be a genuine misunderstanding on someone's part, I don't plan to single them out by name. Doing that can make it feel more personal and more critical than it is intended to be.

Instead, I'll quote them anonymously here, in order to focus on the ideas, and to involve us all in the search for the right path.

 


As a teacher of, and a research scientist in, anatomy, it absolutely warms my heart when I see people using anatomical reasoning to try to figure out how the body works, why something might not be working as we would expect or want it to, and what we might be able to do to help support it returning to optimal function.

When I see someone applying anatomical reasoning to assess a client's situation and make a recommendation to improve care, as Kim LeMoon does here:

In reviewing Louisa's case, the possibility of lumbar radiculopathy was reconsidered. A previously overlooked sign was that the injury had occurred during a twisting motion. The lumbar intervertebral discs are thought to be more vulnerable to herniation in rotation. Between the clinical pattern recognition and Louisa's report of hearing a "loud pop" during a twisting motion, the new hypothesis was that Louisa may have herniated a lumbar disc and that lumbar radiculopathy could be the source of her referred pain symptoms. I described the hypothesis to Louisa and advised her to seek the advice of an orthopedic surgeon.

During this time, for reasons unknown, Louisa had started working with a different chiropractor. She was asked to describe the hypothesis to the new chiropractor to solicit his opinion.

Results

The chiropractor considered the new hypothesis plausible and referred Louisa to an orthopedic surgeon who specializes in treating low back pain. As a result of a magnetic resonance imaging investigation ordered by the surgeon, an L5-S1 herniation was found.

 

I do a little happydance, often literally or sometimes, if I'm in a public place, figuratively.

I'm also very pleased to see the openness to evolutionary biological explanations among members of the MT community. Based on my experience (and, of course, as we know, the plural of "anecdote" is NOT "data"), I'm under the impression that there is very little actual evolution denial in the MT community, when compared to the larger American public.

The following graph shows where the US rates in knowledge of evolution, as measured by their acceptance of the statement of a non-controversial statement based on foundational biological knowledge.

http://upload.wikimedia.org/wikipedia/commons/5/5c/Views_on_Evolution.svg accessed 5 April 2012

 

Only 40% of Americans got the correct answer, "true", compared with about 75-80% in countries such as the Scandinavian nations, and France, Japan, and Germany.

While the American public at large's knowledge and acceptance of evolutionary biology comes in almost last among developed countries (ahead only of Turkey), I don't see that in the MTs I come into contact with. They seem open to anatomical explanations and reasoning grounded in rigorous biological science.

The only wrinkle is, if you're going to use evolutionary explanations, you need to be sure you're getting the science right. Otherwise, rather than actually explaining or understanding, you're only passing along yet another "just-so story".

When this anatomy teacher sees MTs making statements such as:

If, besides sensing temperature, skin was truly as vital as scientists claim it is, wouldn't the body protect it better?

 

then I would say to the MT, "It is very good that you are grappling with your questions in this way. There are a couple of pieces of information you need, in order to make sure you stay on track with what you want to figure out.".

First, of course, a review of the skin's barrier function is in order.

But, significantly, this MT is clearly open to evolutionary explanations, in the linkage between the survival value of the skin's function and the body's "investment" in it.

The problem is that, as we humans often do, this practitioner has fallen into a pattern of teleological, or goal-directed (from Ancient Greek τέλος/telos, purpose) + λόγος/logos, word, speech, discourse), thought, and then applies that teleological thinking in an arena where it doesn't apply--that is, evolution.

Evolution is a blind, unguided process--the body doesn't "decide" to "protect" the skin. It's the other way around--those organisms that happened to develop protective barriers happened to survive longer, because of the survival value those barriers provided, than those that didn't have them.

So in that longer time, they had more offspring, who then were able to out-reproduce the offspring of organisms without those barriers, and this cycle continued for thousands of generations.

There's no "why" for the body to make a decision about. There's just what anatomy came about blindly back in the deep past, and what physiological and pathological consequences resulted from that chance development.

With that bit of foundational knowledge from evolutionary biology, this MT is much more likely to find the answer they are seeking than by continuing down the path of teleological thinking about anatomy.

Another example of a question from an MT wanting to know about the brain puts them right on the verge of an important discovery:

Earlier you said the brain had an old bossy part and some younger naive parts that don't get along with each other. I'd consider that mismatch to be a systemic flaw. With all those faults why would MTs even want to work with the brain?

 

Yes! You're almost there! You're so close!

Yes, there are old bossy parts of the brain that don't get along with the younger naive parts (h/t Diane Jacobs for the terminology!).

Yes, that is a systemic flaw.

And that's one of the threads in the multiple lines of evidence for evolutionary biology, and that reinforces it as a basis for anatomical reasoning--if the body were specially created by a designer, you'd expect it to work better than having parts of the brain that don't play well together, or Kim LeMoon's client having the inherent weakness in the lumbar discs that come from starting to walk on 2 legs at some point in our history as modern humans, or hundreds of other examples that a brief glance at any A&P/pathology book will provide.

So it's not that the neuroscientist is mistaken, as the MT thought by finding that flaw--scientists know that already.

If you understand that parts of our anatomy are systemically flawed--and that that's ok by evolution, because evolution doesn't teleologically "seek" a perfect solution; it blindly makes do with a "good-enough" workaround--then you are that much further to being able to apply real and solid anatomical reasoning and gain understanding that puts you in a position to help clients better.

We work with the systemically flawed human brain (and some of us with the brains of other animals as well), because that's what we have before us. We meet the clients where they really and truly are right now, not where we might want them to be in a different universe that operated by different rules, and provided them with perfectly-optimized brains.

That's the demonstrated need for evolutionary biological information to support clinical reasoning that I'm planning to meet with POEM's introductory evolutionary biology for MTs e-Book. At the moment, I project it will be available in 2.5-3 years (roughly, between November 2014 and May 2015), after the research literacy book and several others that are more directly connected to the material tested on MT certification exams.

 

 

http://upload.wikimedia.org/wikipedia/commons/d/dd/Horseevolution.png accessed 5 April 2012

"A very sad dinosaur"


Cancer is different from other diseases, because cancers are not natural to the Universe. The man-made chemicals that cause cancers are foreign to the Universe. Man created the cancer; Man must treat the cancer, by killing or excising the cancer. Because Man created the cancer: Man must kill it.
 
--variations on this idea have been seen around the net on different MT forums
 
 

This article is an older one, but since we're talking about brains this month, it is still timely. It contains interesting information both about cancer, and about the scientific method--how scientists know about things that happened millions of years before any of us were ever born.
 
 
On October 23, [2003,] a team of paleontologists and pathologists announced that they had discovered a massive, possibly lethal brain tumor in the fossilized skull of a Gorgosaurus,
 

Source: http://upload.wikimedia.org/wikipedia/commons/8/80/Gorgosaurus_BW.jpg accessed 7 December 2011
 
 
a 25-foot-long relative of Tyrannosaurus rex
 
 
 
 
 
 
 
that lived 72 million years ago.
 
You can read this as a clock that starts just past noon at 4.6 billion years ago (4.6 Ga). Continuing clockwise, the formation of the earth takes place 4550 million years ago (= 4550 Ma). At 3 billion years ago (3 Ga), 2 Ga, and 1 Ga, things are happening, but life on Earth doesn't really explode into prominence until about 530 Ma with the Cambrian explosion.
 
The dinosaurs lived alongside early mammals from about 230 Ma to 65 Ma, and humans arrived just before midnight on this clock: around 2 Ma.
 
The Cretaceous period, where this case report happened, follows the Jurassic period of Hollywood fame, and both are part of the green band representing the Mesozoic ("middle-life" or "middle-animal") era. Gorgosaurus roamed what would eventually become North America about 75 Ma or so.
 
 
 
 
 
 
Fossils of dinosaur bones are no surprise, but soft tissue doesn't fossilize the same way bones do, which is why we have so little information on dinosaur viscera. How, then, do we have a fossil sample of brain tumor?
 
A matrix of bone within this dinosaur's brain tumor allowed it to fossilize along with the rest of the animal's skeleton.
 
 
 
 
 
The tumor, possibly an unusual type of bone-forming cancer called an extraskeletal osteosarcoma, filled nearly the entire area formerly occupied by the cerebellum and brainstem and probably impaired the cerebrum, the part of the brain that controls thought and memory.
 
How do we know that dinosaur brains work like ours do--that the cerebellum and brainstem control movement and autonomic functions, and that the cerebrum controls thought and memory?
 
Like us, dinosaurs are vertebrates, and moreover--just like us--they are tetrapods.
 
Understandably, this vocabulary might be confusing: τετρά/tetra is Greek for 4, and quadr- is Latin for 4. πόδ/pod is Greek for foot, and ped is Latin for foot. And we know that quadrupeds are animals who walk on all fours, like dogs, cats, and horses, right?
 
So since tetrapod means the same thing in Greek as quadruped means in Latin, and since we're not quadrupeds (we're bipeds), how can we possibly be tetrapods?
 
It's because--although the meanings of the word roots are the same in their respective languages--they've come to mean different things in biology. Tetrapod refers roughly to structure, while quadruped refers roughly to function. So all animals that descended from the paired-limbed fish who evolved into land vertebrates are tetrapods, either because we all have two pairs of limbs (our arms and our legs), or because we used to have them before they changed a great deal (birds' and bats' wings are modified arms), or because we used to have them before they diminished greatly in size (whales, dolphins) or disappeared altogether (snakes).
 
Quadruped, on the other hand, refers to the action of walking on all fours, whether flat-footed like a bear, or on the toes like dogs and cats, or on the toenail, like horses. All of the animals listed in this paragraph are quadrupeds and tetrapods, because they walk on their pairs of limbs. The animals in the previous paragraph, on the other hand, do not walk on all fours--so although they are tetrapods, they are not quadrupeds.
 
So as different as we look on the outside, you see that there is a deep structural similarity we share.
 
And that structural similarity about vertebrate brains is the basis for how we reason about what effects the tumor must have had on this dinosaur when it began compressing structures in her brain.
 
We know how such a tumor affects other vertebrates, and we reason from that similarity about how it must have affected her vertebrate brain.
“As the tumor grew, the dinosaur—a female perhaps three years old— would have forgotten where she left her last kill, and then she would have forgotten to go to the bathroom,” says paleontologist Peter Larson of the Black Hills Institute in Hill City, South Dakota.
 
Sadly, you can see the same progression in loss of function in people living with the effects of brain tumors or other brain conditions. First, it can affect higher-order cerebral functions like thought and memory, but it can progress to a point where the autonomic functions directed by the cerebellum and the brainstem--the ones we don't consciously think about, like breathing or urinating--can be compromised.
The tumor would also have put pressure on the dinosaur’s cerebellum and brain stem, which regulate motor function and other autonomic functions such as heart rate. “The tumor would have impaired mobility and affected the animal’s balance. She would have fallen down a lot,” says veterinary pathologist Rachel Reams of Eli Lilly & Company, who studied the fossil.
 
Usually, as MTs, we don't see clients in this condition, because they are so compromised that other health issues are of much higher priority at that point.
 
Unfortunately for what the poor dinosaur went through, there is physical evidence to back up Reams' inferences about what happened to her.
Larson and his colleagues found ample evidence confirming that conclusion. Throughout the Gorgosaurus’s skeleton, the researchers saw signs of debilitating injuries: a smashed shoulder blade, a bad infection in the lower jaw, broken ribs, and a torn tendon in the left leg. “The leg eventually healed and became useful again, but for a while she would have been dragging that leg around,” Larson says. The creature never recovered from a badly broken right fibula, the small bone of the lower leg. The fracture had healed for barely two weeks at the time of the animal’s death. That was probably the last injury the she suffered, although scientists do not know exactly what killed her. “She was a very sad dinosaur,” says Larson.
 

 


Nobody likes to think of an animal in distress, even as long ago as this happened, and even as scary a predatory beast as she was. The poor sad dinosaur lived and died alone with her disease, experiencing all the problems it created for her quality of life.

The only possible silver lining to suffering is if we can learn something from it that we can, in turn, use to prevent further suffering.

From what the poor Gorgosaurus has taught us through her brief life and awful death in the Cretaceous, how could you change the quotation at the very top so that MTs could share correct information about cancer with other MTs in public forums?

What do we now know about cancer from this 75-million-year-old "case report"?

 


cheers, to Bab Hambilus!

Notes on Guzzetta et al's article, "Massage Accelerates Brain Development and the Maturation of Visual Function", Introduction

These notes are intended to serve as a guide to reading the article by Guzzetta et al. There is a great deal of scientific jargon in the article, and the style is telegraphic--factors which make the article less accessible to people who might otherwise like to read the research for themselves.

This post is intended to accompany a reading of that article, to demystify the jargon for a non-specialist reading audience, to expand the telegraphic style, and to make explicit the implicit knowledge contained within.

The article under study is:

Guzzetta A, Baldini S, Bancale A, Baroncelli L, Ciucci F, Ghirri P, Putignano E, Sale A, Viegi A, Berardi N, Boldrini A, Cioni G, Maffei L. Massage accelerates brain development and the maturation of visual function. Journal of Neuroscience. 2009 May 6;29(18):6042-51. PMID: 19420271 Free fulltext PDF of article available here.
 
Abstract: Environmental enrichment (EE) was shown recently to accelerate brain development in rodents. Increased levels of maternal care, and particularly tactile stimulation through licking and grooming, may represent a key component in the early phases of EE. We hypothesized that enriching the environment in terms of body massage may thus accelerate brain development in infants. We explored the effects of body massage in preterm infants and found that massage accelerates the maturation of electroencephalographic activity and of visual function, in particular visual acuity. In massaged infants, we found higher levels of blood IGF-1. Massage accelerated the maturation of visual function also in rat pups and increased the level of IGF-1 in the cortex. Antagonizing IGF-1 action by means of systemic injections of the IGF-1 antagonist JB1 blocked the effects of massage in rat pups. These results demonstrate that massage has an influence on brain development and in particular on visual development and suggest that its effects are mediated by specific endogenous factors such as IGF-1.
 
 

The first paragraph is pretty straightforward and relatively easily readable, although there are a few points worth remarking upon.

When you read their sentence "EE has remarkable effects on adult brain function in several species", this is a good opportunity to remember that we used to think the adult brain was far less plastic than it turns out to be in reality.

Here, I am using the word "plastic" as in "plastic surgery", meaning that it lends itself to being molded or shaped or formed. The fact that the adult brain is somewhat plastic means that negative experiences in the past that influenced the brain have at least a hope of being recovered from.

Let's review how the visual system works, to ensure that we're all on the same page.

  • Action item (AI) 1/Raven: review of the visual system: I'll post it in this discussion, and in the human systems e-Book, when it is finished--most likely, by end of day (EOD) Monday.

 

"Appreciable" means empirically detectable, measurable.

  • AI 2/Raven: put definition of "appreciable" in the wiki.
 
 
For many of us--not all, since massage education in the United States is so variable--one of the first things we learned in anatomy and physiology class was the various levels of analysis that we could look at in an anatomical structure and its physiological function. Even so, those we learned did not represent all possible levels, but just the ones most useful at the beginning, such as the gross anatomical level or the systems level.
 
  • Question 1: Can you give an example of a structure and its function at the behavioral level, at the electrophysiological level, and at the molecular level?
 


There is a lot of technical language in the 2nd paragraph, but it really refers to only a few foundational concepts. Once you know how, for example, a BDNF receptor works, you will understand how an NMDA receptor works when you come across it, because it's the same general idea--the specific molecule involved is the only change.

So don't let a skim of this paragraph discourage you--it's not nearly as hard as it looks at first glance.

  • Question 2: What seems to be the cause-and-effect connection between EE and improved function and behavior in pups?
  • Question 3: Can you think of an analogy in human behavior? Remember, we are not claiming that we know that this is true, but that it could possibly serve as a testable hypothesis for further study.
 
 
"[L]icking and grooming provided by the mother has been shown to influence [here, positive influence is implied]: 

 

Although there remains a lot that we don't know about what the hippocampus does, it is fairly well-established that it plays a major role both in memory and in spatial coding (mental representations of the spatial relations between objects). [1]

 


Guzzetta also states that the level of licking and grooming provided by the mother affects molecules crucial for plasticity, meaning the brain's ability to be shaped or formed in new ways and to form new connections, rather than being frozen and relatively unable to change.

In this context of the brain, this refers to proteins and other molecules that promote the growth and development of brain cells (a process called neurogenesis), since the dynamics governing that growth and development is where plasticity comes from.

BDNF, short for Brain-Derived Neurotrophic Factor, is:

  • is a protein expressed by the BDNF gene;
  • is a growth factor;
  • is involved in neurogenesis;
  • is suppressed in cases of depression;
  • increased by the neurotransmitter glutamate, exercise, caloric restriction, intellectual stimulation
  • active and present in high concentrations in brain areas vital to learning, memory, and higher thinking, such as the hippocampus and cortex. [2]
 
 

NMDA, short for N-Methyl-D-aspartic acid, is a molecule that mimics the action of the neurotransmitter glutamate, so it can stand in for glutamate when investigating the neurotransmitter's action under certain circumstances.

 
 
 
 

 
  • novelty reaction
  • exploratory behavior
 
Exploration is the act of making the unknown known and is a fundamental adaptive behavior across many species. A related adaptive behavior is novelty seeking, defined as a proclivity to approach unfamiliar situations. Abnormal exploratory behavior and novelty seeking are characteristic of many neuropsychiatric conditions, including excessive activity observed in bipolar mania, increased novelty seeking in substance use disorders, and prominent inactivity and withdrawal as observed in schizophrenia. For several decades, numerous animal paradigms of neuropsychiatric illness have assessed the multiple dimensions of exploratory behavior and novelty seeking. These models have been useful in elucidating underlying neurobiological mechanisms and testing novel psychotropic treatments. [3]
 
 
 

  • spatial learning and memory
  • level of glucocorticosteroid receptors in the hippocampus
Glucocorticoids are steroid hormones that play a role in reducing inflammation and in normal brain development. [4]
 
  • feedback control on hypothalamus-pituitary-adrenal axis
The hypothalamic–pituitary–adrenal (HPA) axis is a major system of hormonal control over many functions in the body. Much like a thermostat uses surrounding heat to tell if it needs to continue heating or to turn off the heat, the HPA axis checks blood levels of circulating hormones to determine whether to stimulate or stop stimulating hormone production in the glands in the system.
 
  • spine density and synaptic plasticity in hippocampus
This refers to the structure and plasticity of neurons in the hippocampus.
 
 

negative effects produced by maternal separation/deprivation or prenatal stress on:
  • pup growth
  • growth hormone (GH) secretion

Growth hormone, secreted by the anterior pituitary gland, plays a major role in structure growth and regulation of other hormonal systems in the body, such as the production of IGF-1.

 

 
 
 
 
 
  • HPA axis
  • BDNF expression
  • synaptophysin expression

Synaptophysin is a protein expressed by the SYP gene. The exact function of the protein is unknown...Recent research has shown, however, that elimination of synaptophysin in mice creates behavioral changes such as increased exploratory behavior, impaired object novelty recognition, and reduced spatial learning. [5]

 

 
"rescued": here it means "mitigated", or "alleviated"
 
"Working in preterm infants, Schanberg and Field (1987) found evidence that massage promoted a faster weight gain and a lower level of cortisol in massaged infants."
 
  • Question 4: What's wrong with this sentence?
 
 

Paragraph 3 is relatively straightforward and easy to understand.
 
 

Paragraph 4
 
Visual evoked potentials (VEPs) are measurements of electrical activity in the nervous system after some source of visual stimulation has occurred. For example, an investigator might use VEPs to trace the activity in the brain to see what happens when the subject is watching a flashing light.
 
Visual acuity is the sharpness or clearness of someone's vision--how clearly they can see.
 
Source: http://upload.wikimedia.org/wikipedia/commons/9/9f/Snellen_chart.svg accessed 4 December 2011
 
 
 
Electroencephalography (EEG) is the measurement of the brain's electrical activity
 
 
 
by means of electrodes placed along the scalp.
 
 
 
 
 
 
 

In paragraph 5, Guzzetta states that "IGF-1 mediates EE effects on visual cortical development". To "mediate" means to be in the middle of other things. Let's say the independent variable (roughly, the "cause") in the following figure is EE, and the dependent variable (roughly, the "effect") is visual cortical development.

Path C shows a connection where EE directly causes visual cortical effects. But here, Guzzetta is saying that that is not the case--instead, EE has an effect on IGF-1 (path A), and IGF-1 then has an effect on visual cortical effects (path B). IGF-1, then, mediates (is a mediator variable between) EE effects and visual cortical development.

 
 
 
 
So now that we've established the role that Guzzetta's team proposes it plays in mediating the effects of EE into visual cortex development, let's talk about what IGF-1 is.
 
IGF-1:
  • is a protein molecule, encoded by the IGF1 gene, that functions as a hormone;
  • is named Insulin-like Growth Factor 1:
    • "Insulin-like" because of its structural similarity to insulin;
    • "Growth Factor" because of its lifelong anabolic role;
    • "1" because it is a member of a family of structurally-related proteins, such as IGF-2;
  • is produced mostly by the liver;
  • is a primary mediator of Growth Hormone (GH);
  • appears to play a major role in biological aging and cancer, as well as in normal growth. [6]
 
 
 
How it works:
  1. the anterior pituitary in the brain produces GH, and releases it into the blood;
  2. GH goes to the liver, and stimulates it to produce IGF-1, and release it into the blood;
  3. IGF-1 causes growth in many different kinds of cells in the body, including the ones we're interested in here: the visual cortical cells in the occipital lobe.
     
Guzzetta also states that EE increases the number of IGF-1-positive neurons in the visual cortex; this is an example of neurogenesis.
 
They describe how increasing IGF-1 in the visual cortex of non-EE rats by means of osmotic minipumps mimics EE effects, accelerating visual acuity development.
 
An osmotic minipump is a tiny implantable device that delivers IGF-1, which the rat's cells then take up by osmosis.
  • AI 3/Raven: finish demonstration of diffusion, use that to lead into osmosis
 
 
The visual cortex is the part of the brain that processes information delivered from the eyes. This is the brain of a person whose hair, skin, and skull have been digitally removed from the image.
 
The person is facing away from you, so you are looking at the back of their head: the occipital lobe.
 
A funny thing is that--although the eyes are in the front of the head, the information they deliver has to travel all the way to the back to be processed, and then is projected all the way back up front to the eyes again, which gives the perception that vision is in our eyes.
 
 
The name "visual cortex" tells us that it's in the cortex, or outer layer of the cerebrum--the darker purple in this picture of a slice of brain tissue; the gray matter of the brain, as opposed to the inner layer of white matter.
 
 
 
 
 
Guzzetta observes that blocking IGF-1 action in the visual cortex of EE rats by means of the IGF-1 receptor antagonist JB1 blocks EE action on visual acuity development. JB-I blocks IGF-I signaling; in the following discussion of antagonists, we'll discuss in more detail how it does so.
 
They also observe that massage led to increased levels of blood IGF-1 and IGF1BP3 in human infants. IGFBP-3 is a carrier or a binding protein for IGF-1, preventing the kidney from quickly clearing it from the blood, as it normally would. [6]
 
Guzzetta states that massage led to increased number of IGF-1 positive neurons in the cortex in rat pups.
  • Question 5: Why didn't they test this in human infants?
 
 
Guzzetta also observes that antagonizing IGF-1 action blocked the effects of massage in rat pups. You can think of an antagonist at a molecular level as being both similar to and different from an antagonist at the muscular level.
 
Like a muscular antagonist, a molecular antagonist works against, or opposes, another molecule. But the way in which it opposes that other molecule is not like how an antagonist muscle works.
 
A molecular antagonist is similar enough to the other molecule that it can slip into the "lock-and-key" receptor, and block it off, so that when the other molecule arrives, it cannot find a receptor to take it up.
 
So Guzzetta is saying that they hypothesize that the effects of massage are mediated by IGF-1, and the fact that an IGF-1 antagonist blocked the effects of massage reinforces the hypothesis that massage affects the visual cortical neurons in a way that is mediated by IGF-1.
  • Question 6: Why didn't they test this in human infants?
 
  • Question 7: What is the purpose of Guzzetta's study?
Imagine you're explaining it to someone you just met at a party, or on the bus, not in the lab or clinic--use that level of language, rather than Guzzetta's jargon.
 
  • Question 8: What did they say about their results in this paragraph?
 
 
 

References

[1] Wikipedia: Hippocampus accessed 4 December 2011

[2] Wikipedia: BDNF accessed 4 December 2011

[3] Minassian A, Henry BL, Young JW, Masten V, Geyer MA, Perry W. Repeated assessment of exploration and novelty seeking in the human behavioral pattern monitor in bipolar disorder patients and healthy individuals. PLoS One. 2011;6(8):e24185. PMID: 21912623

[4] Wikipedia: Glucocorticoid accessed 4 December 2011

[5] Wikipedia: Synaptophysin accessed 4 December 2011

[6] Wikipedia: IGF-1 accessed 4 December 2011

 

Canine PTSD and the case for interdisciplinary learning

Reading this story in the New York Times this morning, I was struck by not only the content of the story--which is important, and which I'll bring up over at Journal Club, where we're discussing massage for female veterans with PTSD--but also by the very topic.

After Duty, Dogs Suffer Like Soldiers 

By JAMES DAO
Published: December 1, 2011

SAN ANTONIO — The call came into the behavior specialists here from a doctor in Afghanistan. His patient had just been through a firefight and now was cowering under a cot, refusing to come out.

Post-traumatic stress disorder, thought Dr. Walter F. Burghardt Jr., chief of behavioral medicine at the Daniel E. Holland Military Working Dog Hospital at Lackland Air Force Base. Specifically, canine PTSD.

If anyone needed evidence of the frontline role played by dogs in war these days, here is the latest: the four-legged, wet-nosed troops used to sniff out mines, track down enemy fighters and clear buildings are struggling with the mental strains of combat nearly as much as their human counterparts. [1]

 
 

Among many people in my family, as well as some I grew up with, the concept of a psychological condition like canine PTSD is laughable--or it would be, if they did not find it so offensive and disrespectful. 

They are firmly committed to the idea of human exceptionalism: the idea that humans are categorically special and different from other animals by virtue of human cognition, emotions, and other features of our brains and minds.

There is nothing wrong at all with wanting to feel special--without that impetus, the entire corpus of unique human self-expression, such as paintings, sculptures, and poetry, would not exist. Nor, probably, would large parts of the motivation behind exploring universals in knowledge.

At some level, everyone wants to feel special, and there is no mistake in that, as long as that feeling is not used as a filter for evaluating evidence.

The problem lies in accepting or rejecting evidence based on whether it reinforces our feeling of specialness rather than on whether the evidence itself is valid or trustworthy.

If you choose to think that only humans are capable of tool use, or self-awareness, or emotions, or of moral value judgments, or of cultural learned behavior, or of problem-solving, then you have to ignore a great deal of accumulated evidence that contradicts those views.

 

 

These traits may appear rudimentary or different in other animals, compared to how humans express them, but that does not necessarily mean that the underlying neural mechanisms are qualitatively or essentially different.

To accept the evidence of those cognitive, emotional, and psychological processes in other animals that we had once thought only humans were capable of is not to diminish or insult humans as a result. It is perfectly reasonable to say both that humans in distress are worthy of caring for, and that animals in distress are also worthy of caring for--it is not a zero-sum game, where one detracts from the other.

In my opinion, a passing acquaintance with foundational knowledge in the following disciplines would be very useful for a better understanding among MTs about our natural world, and--through that understanding--about how we can better provide help, support, and service to our clients:

  • evolutionary biology: the structural and functional similarities and differences among animals (including ourselves) over time, and what we know about the genetics/genomics involved in those similarities and differences;
  • comparative neuroscience: what we know about the brains and minds of other species, and what insight that knowledge provides about our own;
  • comparative psychology: what we know about the minds and behavior of other species, and what insight that knowledge provides about our own;
  • comparative history of ideas: what we have thought about the world around us at certain parts of our history in light of what we knew at the time, and the effect those ideas have had upon us and upon our environment.

 

That's why POEM is committed to providing high-quality, validated, universally accessible, and user-friendly information resources in all these areas, and more.

 

Source: http://graphics8.nytimes.com/images/2011/12/02/us/02canine/02canine-articleLarge-v2.jpg accessed 2 December 2011

 


References

[1] New York Times: More Military Dogs Show Signs of Combat Stress accessed 2 December 2011 

 

 

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